| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-02-09 |
| タイトル |
|
|
タイトル |
DIRECT EFFECT OF PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY ON THE HEART IN PATIENT WITH PERIPHERAL ARTERY DISEASE |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
peripheral artery disease |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
percutaneous transluminal angioplasty |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
B-type natriuretic peptide |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
augmentation index |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
central aortic pressure |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Oguma, Yasunori
Iino, Kenji
Watanabe, Hiroyuki
Kosaka, Toshimitsu
Hasegawa, Hitoshi
Ito, Hiroshi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background and Purpose : The patient with peripheral artery disease (PAD) is known to have a poor prognosis for life. Recently, it has been reported that percutaneous transluminal angioplasty (PTA) for PAD improves the prognosis. However, the detailed mechanisms remain unclear. Augmentation index (AIx) or central aortic pressure (CAP) is shown to increase myocardial mechanical stress and facilitate myocardial hypertrophy. The aim of this study is to clarify the direct cardioprotective effects of PTA mediated by decreasing CAP and AIx. Methods : 28 patients with PAD were enrolled. They were divided into two groups ; control group (n=12) and PTA group (n=16). Both radial AIx and CAP were measured by using pulse waveform analysis of arterial waveform recorded non-invasively by applanation tonometry in radial artery. We used a plasma B-type natriuretic peptide (BNP) level as a marker of myocardial mechanical stress. Plasma BNP levels, radial AIx and CAP which were measured after PTA or angiography, were compared with the data on admission. Result : Although plasma BNP levels in the control group were not changed, those in the PTA group were significantly decreased from 68.44 to 42.08 pg/ml (p<0.05). Pulse waveform analysis demonstrated that radial AIx and CAP in the control group remain unchanged. On the other hand, radial AIx and CAP were significantly reduced in the PTA group. The reduction rates of radial AIx, CAP and plasma BNP levels were −11.3%, −8.9% and −34% respectively. Conclusion : These results suggest that PTA can decrease myocardial mechanical stress in patients with PAD. The mechanisms may be mediated in part by reduction of radial AIx and CAP. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 36,
号 2,
p. 107-113,
発行日 2009-11-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
p107-113.pdf (902.0 kB)
