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Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients
http://hdl.handle.net/10295/00005838
http://hdl.handle.net/10295/00005838f7066300-55c8-4595-affc-d8a75189129d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
byoA_2021_2 (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
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| 公開日 | 2021-11-25 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients | |||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||
| 主題 | ||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||
| 主題 | tacrolimus | |||||||||||||||||||||||||
| 主題 | ||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||
| 主題 | everolimus | |||||||||||||||||||||||||
| 主題 | ||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||
| 主題 | CYP3A5 polymorphism | |||||||||||||||||||||||||
| 主題 | ||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||
| 主題 | renal transplantation | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||
| 作成者 |
Kagaya, Hideaki
× Kagaya, Hideaki
× Niioka, Takenori
× Saito, Mitsuru
× Inoue, Takamitsu
× Numakura, Kazuyuki
× Yamamoto, Ryohei
× Akamine, Yumiko
× HABUCHI, Tomonori
× SATOH, Shigeru
× Miura, Masatomo
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| 内容記述 | ||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||
| 内容記述 | While tacrolimus and everolimus have common metabolic pathways through CYP3A4/5, tacrolimus is metabolized solely by CYP3A4 in recipients with the CYP3A5*3/*3. The purpose of this study was to evaluate how the area under the blood concentration-time curves (AUC) of tacrolimus could be predicted based on CYP3A5 genotype and the AUC of everolimus in renal transplant patients taking both drugs. The dose-adjusted AUC (AUC/D) of tacrolimus and everolimus were calculated at one month and one year after transplantation. Significant correlations between the AUC/D of tacrolimus and everolimus were found for patients with the CYP3A5*1 allele or CYP3A5*3/*3 at both one month and one year. At both stages, the determination coefficients were higher and the slopes of regression equations were larger for patients with CYP3A5*3/*3 compared to the CYP3A5*1 allele. A good correlation between single doses of tacrolimus and everolimus was found for CYP3A5*3/*3 patients at 1 year after transplantation (r = 0.794, p < 0.001). The variability of the AUC0–24/D of tacrolimus for each CYP3A5 genotype could be predicted based on the AUC0–12/D of everolimus. Clinicians may be able to comprehensively carry out the dose adjustments of tacrolimus and everolimus based on relationship with AUCs of both drugs in each CYP3A5 genotype. | |||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| 書誌情報 |
International Journal of Molecular Sciences 巻 19, 号 3, p. 882, 発行日 2018 |
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| 収録物識別子 | ||||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 1422-0067 | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||||||||||
| 関連情報 | ||||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/ijms19030882 | |||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||
| 権利情報 | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||||
