WEKO3
アイテム
{"_buckets": {"deposit": "434e373c-afb5-4e34-a7a1-150da1ad0343"}, "_deposit": {"created_by": 3, "id": "2288", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2288"}, "status": "published"}, "_oai": {"id": "oai:air.repo.nii.ac.jp:00002288", "sets": ["1003"]}, "author_link": ["8598", "8600", "8597", "8599"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03-31", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3/4", "bibliographicPageEnd": "134", "bibliographicPageStart": "127", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "秋田医学"}]}]}, "item_10001_description_5": {"attribute_name": "内容記述(抄録)", "attribute_value_mlt": [{"subitem_description": "Chronic lung disease (CLD) of the newborn is a major problem in neonatology. Activation of alveolar macrophages has been implicated in the pathogenesis of CLD. Acid sphingomyelinase (ASM) responds to diverse cellular stressors, including lipopolysaccharide (LPS) stimulation. Recently, functional inhibitors of acid sphingomyelinase (FIASMAs) have been described as a large group of compounds that inhibit ASM. Here, we used maternal intra-peritoneal LPS injection to model CLD in the infant rat lung. Using this model, we studied ASM activity in the infant rat lung and the effects of FIASMAs on release of interleukin-6 (IL-6) from LPS-stimulated alveolar macrophages. Maternal exposure to LPS non-significantly increased ASM activities in the infant rat lung. FIASMAs significantly decreased ASM activity of LPS-stimulated alveolar macrophages. In addition, some FIASMAs suppressed the release of IL-6 from LPS-stimulated alveolar macrophages during the early response phase. However, FIASMAs did not suppress the release of IL-6 from LPS-stimulated alveolar macrophages. From our study, we could not confirm that ASM activation is responsible for LPS-related pathogenesis of CLD and release of IL-6 from LPS-stimulated alveolar macrophages.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "秋田医学会"}]}, "item_10001_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00009294", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03866106", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ito, Tomoo"}], "nameIdentifiers": [{"nameIdentifier": "8597", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oyama, Chikako"}], "nameIdentifiers": [{"nameIdentifier": "8598", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arai, Hirokazu"}], "nameIdentifiers": [{"nameIdentifier": "8599", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "8600", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "akitai40-3_4(127).pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "akitai40-3_4(127).pdf", "url": "https://air.repo.nii.ac.jp/record/2288/files/akitai40-3_4(127).pdf"}, "version_id": "6bd65cb4-daa4-4428-b449-a43c0fb77603"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "chronic lung disease of the newborn", "subitem_subject_scheme": "Other"}, {"subitem_subject": "alveolar macrophage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "acid sphingomyelinase", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "No Involvement of Acid Sphingomyelinase in the Secretion of IL-6 from Alveolar Macrophages in Rat", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "No Involvement of Acid Sphingomyelinase in the Secretion of IL-6 from Alveolar Macrophages in Rat"}]}, "item_type_id": "10001", "owner": "3", "path": ["1003"], "permalink_uri": "http://hdl.handle.net/10295/2502", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-06-16"}, "publish_date": "2014-06-16", "publish_status": "0", "recid": "2288", "relation": {}, "relation_version_is_last": true, "title": ["No Involvement of Acid Sphingomyelinase in the Secretion of IL-6 from Alveolar Macrophages in Rat"], "weko_shared_id": 3}
No Involvement of Acid Sphingomyelinase in the Secretion of IL-6 from Alveolar Macrophages in Rat
http://hdl.handle.net/10295/2502
http://hdl.handle.net/10295/250294af9c0d-34df-47a9-93fa-67c6f922bf95
名前 / ファイル | ライセンス | アクション |
---|---|---|
akitai40-3_4(127).pdf (1.3 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-06-16 | |||||
タイトル | ||||||
タイトル | No Involvement of Acid Sphingomyelinase in the Secretion of IL-6 from Alveolar Macrophages in Rat | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic lung disease of the newborn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alveolar macrophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acid sphingomyelinase | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ito, Tomoo
× Ito, Tomoo× Oyama, Chikako× Arai, Hirokazu× Takahashi, Tsutomu |
|||||
内容記述(抄録) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chronic lung disease (CLD) of the newborn is a major problem in neonatology. Activation of alveolar macrophages has been implicated in the pathogenesis of CLD. Acid sphingomyelinase (ASM) responds to diverse cellular stressors, including lipopolysaccharide (LPS) stimulation. Recently, functional inhibitors of acid sphingomyelinase (FIASMAs) have been described as a large group of compounds that inhibit ASM. Here, we used maternal intra-peritoneal LPS injection to model CLD in the infant rat lung. Using this model, we studied ASM activity in the infant rat lung and the effects of FIASMAs on release of interleukin-6 (IL-6) from LPS-stimulated alveolar macrophages. Maternal exposure to LPS non-significantly increased ASM activities in the infant rat lung. FIASMAs significantly decreased ASM activity of LPS-stimulated alveolar macrophages. In addition, some FIASMAs suppressed the release of IL-6 from LPS-stimulated alveolar macrophages during the early response phase. However, FIASMAs did not suppress the release of IL-6 from LPS-stimulated alveolar macrophages. From our study, we could not confirm that ASM activation is responsible for LPS-related pathogenesis of CLD and release of IL-6 from LPS-stimulated alveolar macrophages. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
書誌情報 |
秋田医学 巻 40, 号 3/4, p. 127-134, 発行日 2014-03-31 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03866106 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00009294 | |||||
出版者 | ||||||
出版者 | 秋田医学会 |