A CASE WITH HYPOCRETIN(OREXIN) DEFICIENT NARCOLEPSY, PARKINSON’S DISEASE AND SEVERE PSYCHOSIS WAS SUCCESSFULLY TREATED BY MODIFIED ELECTRO-CONVULSIVE THERAPY
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We report the case of a 60-year-old male who exhibited severe psychosis two years after beginning
treatment with methylphenidate for hypocretin deficient narcolepsy. He also suffered from
Parkinson’s disease (PD) and was treated by several medications. The psychotic episode persisted
several weeks after medication cessation and required management with modified electroconvulsion
therapy. Physicians should be aware that psycho-stimulants and anti-PD medications
commonly prescribed for treatment of narcolepsy and PD may precipitate psychosis in those
patients.