{"created":"2023-07-25T10:25:34.547243+00:00","id":5975,"links":{},"metadata":{"_buckets":{"deposit":"659a754f-542f-485f-adb5-bb1b6f6886c0"},"_deposit":{"created_by":15,"id":"5975","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5975"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005975","sets":["611:939:940"]},"author_link":[],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"SCIENTIFIC REPORTS","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated. The PRCA2004/2006 study showed that poor responses to immunosuppression and anemia relapse were associated with death. PRCA may represent the prodrome to MDS. Thus, clonal hematopoiesis may be responsible for treatment failure. We investigated gene mutations in myeloid neoplasm-associated genes in acquired PRCA. We identified 21 mutations affecting amino acid sequences in 11 of the 38 adult PRCA patients (28.9%) using stringent filtering of the error-prone sequences and SNPs. Four PRCA patients showed 7 driver mutations in TET2, DNMT3A and KDM6A, and 2 PRCA patients carried multiple mutations in TET2. Five PRCA patients had mutations with high VAFs exceeding 0.3. These results suggest that clonal hematopoiesis by stem/progenitor cells might be related to the pathophysiology of chronic PRCA in certain adult patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research","subitem_publisher_language":"en"}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-021-81890-5","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujishima, Naohito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kohmaru, Junki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Koyota, Souichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuba, Keiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saga, Tomoo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Omokawa, Ayumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Moritoki, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ueki, Shigeharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishida, Fumihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakao, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuda, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohta, Akiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tohyama, Kaoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamasaki, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Usuki, Kensuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakashima, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Shinya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nannya, Yasuhito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ogawa, Seishi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawada, Kenichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mitani, Kinuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirokawa, Makoto","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-25"}],"displaytype":"detail","filename":"iA_2022_113.pdf","filesize":[{"value":"837.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_113.pdf","url":"https://air.repo.nii.ac.jp/record/5975/files/iA_2022_113.pdf"},"version_id":"4d9b50a9-1ce6-4887-9672-f9772f64d584"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clonal hematopoiesis in adult pure red cell aplasia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clonal hematopoiesis in adult pure red cell aplasia","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-25"},"publish_date":"2023-02-25","publish_status":"0","recid":"5975","relation_version_is_last":true,"title":["Clonal hematopoiesis in adult pure red cell aplasia"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-22T23:15:51.280745+00:00"}