{"created":"2023-07-25T10:25:34.459563+00:00","id":5973,"links":{},"metadata":{"_buckets":{"deposit":"8dd16d66-5daf-4b7b-855d-fdc1f4fa5306"},"_deposit":{"created_by":3,"id":"5973","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5973"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005973","sets":["611:939:940"]},"author_link":["17892","17887","17896","17882","17879","17888","17894","17893","17895","17891","17880","17886","17885","17881","17889","17884","17890","17883","17897"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"SCIENTIFIC REPORTS"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"We evaluated the impact of early changes in serum biomarker levels on the survival of patients with metastatic hormone-sensitive prostate cancer (mHSPC) who were initially treated with androgen deprivation therapy (ADT). We retrospectively investigated 330 patients with mHSPC whose serum maker levels were at baseline and at 2-4 months. An optimal Cox regression model was established with the highest optimism-corrected concordance index based on 10-fold cross-validation. The median cancer-specific survival (CSS) and overall survival (OS) were 7.08 and 6.47 years (median follow-up, 2.53 years), respectively. In the final optimal Cox model with serum biomarker levels treated as time-varying covariates, prostate-specific antigen (PSA), hemoglobin (Hb), and alkaline phosphatase (ALP) significantly increased the risk of poor survival in the context of both CSS and OS. Kaplan-Meier curves stratified by the three risk factors of high PSA, low Hb and high ALP desmondtated that median OS were not reached with none of these factors, 6.47 years with one or two factors, and 1.76 years with all three factors. Early changes in serum biomarker levels after ADT may be good prognostic markers for the survival of patients with mHSPC.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-019-48600-8","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1038/s41598-019-48600-8"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/s41598-019-48600-8","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2019"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Narita, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Kyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatakeyama, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Toshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamura, Sadafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hoshi, Senji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishida, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawaguchi, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishidoya, Shigeto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimoda, Jiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Hiromi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsuzuka, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tochigi, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchiya, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohyama, Chikara"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arai, Yoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagashima, Kengo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Habuchi, Tomonori"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-25"}],"displaytype":"detail","filename":"iA_2022_111.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_111.pdf","url":"https://air.repo.nii.ac.jp/record/5973/files/iA_2022_111.pdf"},"version_id":"d38e7fc0-9de5-4f7c-942f-3df840e35c2e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prognostic significance of early changes in serum biomarker levels in patients with newly diagnosed metastatic prostate cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic significance of early changes in serum biomarker levels in patients with newly diagnosed metastatic prostate cancer"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-25"},"publish_date":"2023-02-25","publish_status":"0","recid":"5973","relation_version_is_last":true,"title":["Prognostic significance of early changes in serum biomarker levels in patients with newly diagnosed metastatic prostate cancer"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T10:38:58.532659+00:00"}