{"created":"2023-07-25T10:25:32.091669+00:00","id":5918,"links":{},"metadata":{"_buckets":{"deposit":"df015fd0-8fb2-4433-8dd7-687cdd639f46"},"_deposit":{"created_by":3,"id":"5918","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5918"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005918","sets":["611:939:940"]},"author_link":["17073","17077","17070","17075","17076","17072","17069","17074","17071"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"BIOMOLECULES"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Galectin-10 is a member of the lectin family and one of the most abundant cytoplasmic proteins in human eosinophils. Except for some myeloid leukemia cells, basophils, and minor T cell populations, galectin-10 is exclusively present in eosinophils in the human body. Galectin-10 forms Charcot-Leyden crystals, which are observed in various eosinophilic diseases. Accumulating studies have indicated that galectin-10 acts as a new biomarker for disease activity, diagnosis, and treatment effectiveness in asthma, eosinophilic esophagitis, rhinitis, sinusitis, atopic dermatitis, and eosinophilic granulomatosis with polyangiitis. The extracellular release of galectin-10 is not mediated through conventional secretory processes (piecemeal degranulation or exocytosis), but rather by extracellular trap cell death (ETosis), which is an active cell death program. Eosinophils undergoing ETosis rapidly disintegrate their plasma membranes to release the majority of galectin-10. Therefore, elevated galectin-10 levels in serum and tissue suggest a high degree of eosinophil ETosis. To date, several studies have shown that galectin-10/Charcot-Leyden crystals are more than just markers for eosinophilic inflammation, but play functional roles in immunity. In this review, we focus on the close relationship between eosinophils and galectin-10, highlighting this protein as a potential new biomarker in eosinophilic diseases.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/biom12101385","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.3390/biom12101385"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.3390/biom12101385","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access\narticle distributed under the terms and conditions of the Creative Commons Attribution\n(CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2218-273X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomizawa, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Yoshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arima, Misaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyabe, Yui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuchi, Mineyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hikichi, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Melo, RossanaC.N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Takechiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueki, Shigeharu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-23"}],"displaytype":"detail","filename":"iA_2022_87.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_87.pdf","url":"https://air.repo.nii.ac.jp/record/5918/files/iA_2022_87.pdf"},"version_id":"23068d6d-931b-4965-bcbc-ba18e53a19b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"eosinophil","subitem_subject_scheme":"Other"},{"subitem_subject":" ETosis","subitem_subject_scheme":"Other"},{"subitem_subject":" eosinophil extracellular trap","subitem_subject_scheme":"Other"},{"subitem_subject":" Charcot-Leyden crystals","subitem_subject_scheme":"Other"},{"subitem_subject":" galectin-10","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Galectin-10 as a Potential Biomarker for Eosinophilic Diseases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Galectin-10 as a Potential Biomarker for Eosinophilic Diseases"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-23"},"publish_date":"2023-02-23","publish_status":"0","recid":"5918","relation_version_is_last":true,"title":["Galectin-10 as a Potential Biomarker for Eosinophilic Diseases"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T10:40:05.248898+00:00"}