{"created":"2023-07-25T10:25:31.030258+00:00","id":5894,"links":{},"metadata":{"_buckets":{"deposit":"953769ff-d12f-4123-adb7-d0e958f6162f"},"_deposit":{"created_by":3,"id":"5894","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5894"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005894","sets":["611:939:940"]},"author_link":["16908","16907","16909","16910","16911","16912","16906"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Apelin is an inotropic and cardioprotective peptide that exhibits beneficial effects through activation of the APJ receptor in the pathology of cardiovascular diseases. Apelin induces the expression of angiotensin-converting enzyme 2 (ACE2) in failing hearts, thereby improving heart function in an angiotensin 1-7-dependent manner. Whether apelin antagonizes the over-activation of the renin-angiotensin system in the heart remains elusive. In this study we show that the detrimental effects of angiotensin II (Ang II) were exacerbated in the hearts of aged apelin-gene-deficient mice. Ang II-mediated cardiac dysfunction and hypertrophy were augmented in apelin knockout mice. The loss of apelin increased the ratio of angiotensin-converting enzyme (ACE) to ACE2 expression in the Ang II-stressed hearts, and Ang II-induced cardiac fibrosis was markedly enhanced in apelin knockout mice. mRNA expression of pro-fibrotic genes, such as transforming growth-factor beta (TGF-beta) signaling, were significantly upregulated in apelin knockout hearts. Consistently, treatment with the ACE-inhibitor Captopril decreased cardiac contractility in apelin knockout mice. In vitro, apelin ameliorated Ang II-induced TGF-beta expression in primary cardiomyocytes, accompanied with reduced hypertrophy. These results provide direct evidence that endogenous apelin plays a crucial role in suppressing Ang II-induced cardiac dysfunction and pathological remodeling.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms20020239","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.3390/ijms20020239"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.3390/ijms20020239","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access\narticle distributed under the terms and conditions of the Creative Commons Attribution\n(CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1422-0067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Teruki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadowaki, Ayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imai, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuba, Keiji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-23"}],"displaytype":"detail","filename":"iA_2022_63.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_63.pdf","url":"https://air.repo.nii.ac.jp/record/5894/files/iA_2022_63.pdf"},"version_id":"75e2774e-10ab-455e-9d16-1a5a8ffa478b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"apelin","subitem_subject_scheme":"Other"},{"subitem_subject":" APJ receptor","subitem_subject_scheme":"Other"},{"subitem_subject":" angiotensin II","subitem_subject_scheme":"Other"},{"subitem_subject":" angiotensin-converting enzyme 2","subitem_subject_scheme":"Other"},{"subitem_subject":" ACE inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":" transforming growth-factor beta","subitem_subject_scheme":"Other"},{"subitem_subject":" heart failure","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-23"},"publish_date":"2023-02-23","publish_status":"0","recid":"5894","relation_version_is_last":true,"title":["Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T10:40:27.655266+00:00"}