{"created":"2023-07-25T10:25:30.460272+00:00","id":5881,"links":{},"metadata":{"_buckets":{"deposit":"f31d1d92-7371-42ac-ad4d-ffdd2a4b989b"},"_deposit":{"created_by":3,"id":"5881","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5881"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005881","sets":["611:939:940"]},"author_link":["16838","16834","16837","16839","16840","16841","16836","16835","16842"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"641","bibliographicPageStart":"635","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"Cancer Science"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Cadmium is a toxic pollutant with occupational and environmental significance, due to its diverse toxic effects. Supramolecules that conjugate and decontaminate toxic metals have potential for use in treatment of cadmium intoxication. In addition, metal-coordinating ability has been postulated to contribute to the cytotoxic effects of anti-tumor agents such as cisplatin or bleomycin. Thiacalixarenes, cyclic oligomers of p-alkylphenol bridged by sulfur atoms, are supramolecules known to have potent coordinating ability to metal ions. In this study, we show that cadmium-coordinated thiacalix[4]arene tetrasulfate (TC4ATS-Cd) exhibits an anti-proliferative effect against T-cell leukemia cells. Cadmium exhibited cytotoxicity with IC50 values ranging from 36 to 129M against epithelia-derived cancer cell lines, while TC4ATS-Cd elicited no significant cytotoxicity (IC50>947M). However, a number of T-cell leukemia cell lines exhibited marked sensitivity to TC4ATS-Cd. In Jurkat cells, toxicity of TC4ATS-Cd occurred with an IC50 of 6.9M, which is comparable to that of 6.5M observed for cadmium alone. TC4ATS-Cd induced apoptotic cell death through activation of caspase-3 in Jurkat cells. In a xenograft model, TC4ATS-Cd (13mg/kg) treatment significantly suppressed the tumor growth of Jurkat cells in mice. In addition, TC4ATS-Cd-treated mice exhibited significantly less cadmium accumulation in liver and kidney compared to equimolar cadmium-treated mice. These results suggest that cadmium-coordinated supramolecules may have therapeutic potential for treatment of T-cell leukemia.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons Inc"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cas.12651","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://doi.org/10.1111/cas.12651"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.1111/cas.12651","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-9032","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhou, Xiaoping"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Muxin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Natsui, Miyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyota, Souichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Yoshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamada, Fumio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugiyama, Toshihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-19"}],"displaytype":"detail","filename":"iA_2022_58.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_58.pdf","url":"https://air.repo.nii.ac.jp/record/5881/files/iA_2022_58.pdf"},"version_id":"a424eba4-3c66-41e5-838c-3e502d42607e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cadmium","subitem_subject_scheme":"Other"},{"subitem_subject":" leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":" supramolecule","subitem_subject_scheme":"Other"},{"subitem_subject":" T-cell receptor","subitem_subject_scheme":"Other"},{"subitem_subject":" thiacalixarene","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-19"},"publish_date":"2023-02-19","publish_status":"0","recid":"5881","relation_version_is_last":true,"title":["Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T10:40:49.512739+00:00"}