{"created":"2023-07-25T10:25:30.284889+00:00","id":5877,"links":{},"metadata":{"_buckets":{"deposit":"43549f43-7104-4dad-b660-b7f158c38064"},"_deposit":{"created_by":15,"id":"5877","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5877"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005877","sets":["611:939:940"]},"author_link":["16802","16803","16804","16805","16806","16807","16808","16809"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"811","bibliographicPageStart":"803","bibliographicVolumeNumber":"107","bibliographic_titles":[{"bibliographic_title":"Cancer Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Cancer tissues have biological characteristics similar to those observed in embryos during development. Many types of cancer cells acquire pro-invasive ability through epithelial-mesenchymal transition (EMT). Similar processes (gastrulation and migration of cranial neural crest cells [CNCC]) are observed in the early stages of embryonic development in Xenopus during which cells that originate from epithelial sheets through EMT migrate to their final destinations. The present study examined Xenopus embryonic tissues to identify anti-cancer compounds that prevent cancer invasion. From the initial test of known anti-cancer drugs, AMD3100 (an inhibitor of CXCR4) and paclitaxel (a cytoskeletal drug targeting microtubules) effectively prevented migration during gastrulation or CNCC development. Blind-screening of 100 synthesized chemical compounds was performed, and nine candidates that inhibited migration of these embryonic tissues without embryonic lethality were selected. Of these, C-157 (an analog of podophyllotoxin) and D-572 (which is an indole alkaroid) prevented cancer cell invasion through disruption of interphase microtubules. In addition, these compounds affected progression of mitotic phase and induced apoptosis of SAS oral cancer cells. SAS tumors were reduced in size after intratumoral injection of C-157, and peritoneal dissemination of melanoma cells and intracranial invasion of glioma cells were inhibited by C-157 and D-572. When the other analogues of these chemicals were compared, those with subtle effect on embryos were not tumor suppressive. These results suggest that a novel chemical-screening approach based on Xenopus embryos is an effective method for isolating anti-cancer drugs and, in particular, targeting cancer cell invasion and proliferation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons Inc"}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/cas.12940","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"©2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltdon behalf of Japanese Cancer Association.This is an open access article under the terms of the Creative CommonsAttribution-NonCommercial-NoDerivs License, which permits use and distributionin any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made."}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1347-9032","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Masamitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuriyama, Sei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itoh, Go","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohyama, Aki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwabuchi, Yoshiharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yashiro, Masakazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aiba, Namiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16809","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-19"}],"displaytype":"detail","filename":"iA_2022_54.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_54.pdf","url":"https://air.repo.nii.ac.jp/record/5877/files/iA_2022_54.pdf"},"version_id":"18d0a7e1-6bb8-4a82-ad0c-aba7082e765d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chemical screening","subitem_subject_scheme":"Other"},{"subitem_subject":" development","subitem_subject_scheme":"Other"},{"subitem_subject":" microtubule","subitem_subject_scheme":"Other"},{"subitem_subject":" tumor invasion","subitem_subject_scheme":"Other"},{"subitem_subject":" Xenopus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of anti-cancer chemical compounds using Xenopus embryos","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of anti-cancer chemical compounds using Xenopus embryos","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-19"},"publish_date":"2023-02-19","publish_status":"0","recid":"5877","relation_version_is_last":true,"title":["Identification of anti-cancer chemical compounds using Xenopus embryos"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-24T14:04:40.238939+00:00"}