| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-02-19 |
| タイトル |
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タイトル |
Macrophage inhibitory cytokine-1 induced by a high-fat diet promotes prostate cancer progression by stimulating tumor-promoting cytokine production from tumor stromal cells |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 主題 |
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主題Scheme |
Other |
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主題 |
macrophage inhibitory cytokine‐ |
| 主題 |
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主題Scheme |
Other |
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主題 |
1 |
| 主題 |
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主題Scheme |
Other |
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主題 |
tumor microenvironment |
| 主題 |
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主題Scheme |
Other |
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主題 |
high‐ |
| 主題 |
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主題Scheme |
Other |
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主題 |
fat diet |
| 主題 |
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主題Scheme |
Other |
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主題 |
prostate cancer |
| 主題 |
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主題Scheme |
Other |
|
主題 |
metabolism |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Huang, Mingguo
Narita, Shintaro
Koizumi, Atsushi
Nara, Taketoshi
Numakura, Kazuyuki
Satoh, Shigeru
Nanjo, Hiroshi
Habuchi, Tomonori
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| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background Recent studies have indicated that a high-fat diet (HFD) and/or HFD-induced obesity may influence prostate cancer (PCa) progression, but the role of HFD in PCa microenvironment is unclear. This study aimed to delineate the molecular mechanisms of PCa progression under HFD milieus and define the stromal microenvironment focusing on macrophage inhibitory cytokine-1 (MIC-1) activation. Methods We investigated the effects of HFD on PCa stromal microenvironment and MIC-1 signaling activation using PC-3M-luc-C6 PCa model mice fed with HFD or control diet. Further, we explored the effect of periprostatic adipocytes derived from primary PCa patients on activation and cytokine secretion of prostate stromal fibroblasts. Expression patterns and roles of MIC-1 signaling on human PCa stroma activation and progression were also investigated. Results HFD stimulated PCa cell growth and invasion as a result of upregulated MIC-1 signaling and subsequently increased the secretion of interleukin (IL)-8 and IL-6 from prostate stromal fibroblasts in PC-3M-luc-C6 PCa mouse model. In addition, periprostatic adipocytes directly stimulated MIC-1 production from PC-3 cells and IL-8 secretion in prostate stromal fibroblasts through the upregulation of adipose lipolysis and free fatty acid release. The increased serum MIC-1 was significantly correlated with human PCa stroma activation, high serum IL-8, IL-6, and lipase activity, advanced PCa progression, and high body mass index of the patients. Glial-derived neurotrophic factor receptor alpha-like (GFRAL), a specific receptor of MIC-1, was highly expressed in both cytoplasm and membrane of PCa cells and surrounding stromal fibroblasts, and the expression level was decreased by androgen deprivation therapy and chemotherapy. Conclusion HFD-mediated activation of the PCa stromal microenvironment through metabolically upregulated MIC-1 signaling by increased available free fatty acids may be a critical mechanism of HFD and/or obesity-induced PCa progression. |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : Cancer Communications
巻 41,
号 5,
p. 389-403,
発行日 2021
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| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2523-3548 |
| 出版者 |
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出版者 |
John Wiley and Sons Inc |
| 関連情報 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/cac2.12137 |
| 権利情報 |
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権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2021 The Authors. Cancer Communications published by JohnWiley & Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center |
iA_2022_36.pdf (3.6 MB)
