{"created":"2023-07-25T10:25:29.450830+00:00","id":5858,"links":{},"metadata":{"_buckets":{"deposit":"06a67f2f-d88b-4807-af9f-b4bcda84c6ed"},"_deposit":{"created_by":15,"id":"5858","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5858"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005858","sets":["611:939:940"]},"author_link":["16633","16634","16635","16636","16637","16638","16639","16640","16641","16642","16643","16644","16645","16646","16647","16648","16649","16650"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"17","bibliographicPageEnd":"5846","bibliographicPageStart":"5839","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Cancer Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Although combination immune checkpoint inhibitor (immuno-oncology [IO]) therapy is the first-line treatment for metastatic renal cell carcinoma (mRCC), it mostly causes resistance and tumor regrowth. Therefore, an optimal second-line therapy is necessary. Such therapy typically comprises vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs). This study was aimed at comparing the efficacy of two TKIs-axitinib and sunitinib-in mRCC patients. From January 2008 to October 2018, we registered 703 mRCC patients from 8 Japanese institutes. Of these, 408 patients received axitinib or sunitinib as the first-line treatment. Thereafter, efficacy and survival rate were compared between the axitinib and sunitinib groups. To reduce the effects of selection bias and potential confounders, propensity score matching analysis was performed. Axitinib and sunitinib were administered in 274 and 134 patients, respectively. More than 25% of the patients received nivolumab sequence therapy. To calculate the propensity scores for each patient, we performed multivariate logistic regression analysis. The objective response rate, progression-free survival (PFS), cause-specific survival, and overall survival (OS) were significantly better in the axitinib group than in the sunitinib group. Furthermore, the OS was better in the nivolumab-treated patients in the axitinib group. Axitinib showed higher efficacy and afforded greater survival benefits than did sunitinib when administered as first-line therapy in mRCC patients. Thus, from among VEGFR-TKIs, axitinib might be a possible option for application in the middle of IO drug-based treatment sequences.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons Inc"}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/cam4.4130","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd."}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2045-7634","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Numakura, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Muto, Yumin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naito, Sei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatakeyama, Shingo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Renpei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koguchi, Tomoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kojima, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawasaki, Yoshihide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kandori, Syuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Sadafumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arai, Yoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Akihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiyama, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kojima, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Obara, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyama, Chikara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchiya, Norihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Habuchi, Tomonori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16650","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-19"}],"displaytype":"detail","filename":"iA_2022_35.pdf","filesize":[{"value":"469.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_35.pdf","url":"https://air.repo.nii.ac.jp/record/5858/files/iA_2022_35.pdf"},"version_id":"867a2755-97f9-4021-a790-532881d82276"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"axitinib","subitem_subject_scheme":"Other"},{"subitem_subject":" metastatic renal cell carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":" nivolumab","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Outcomes of axitinib versus sunitinib as first-line therapy to patients with metastatic renal cell carcinoma in the immune-oncology era","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Outcomes of axitinib versus sunitinib as first-line therapy to patients with metastatic renal cell carcinoma in the immune-oncology era","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-19"},"publish_date":"2023-02-19","publish_status":"0","recid":"5858","relation_version_is_last":true,"title":["Outcomes of axitinib versus sunitinib as first-line therapy to patients with metastatic renal cell carcinoma in the immune-oncology era"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-24T14:03:55.156692+00:00"}