{"created":"2023-07-25T10:25:29.407380+00:00","id":5857,"links":{},"metadata":{"_buckets":{"deposit":"ab32da47-dd24-4508-bbe7-b0171215a6f3"},"_deposit":{"created_by":3,"id":"5857","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5857"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005857","sets":["611:939:940"]},"author_link":["16630","16628","16627","16631","16629","16632"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"439","bibliographicPageStart":"434","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Neuropsychopharmacology Reports"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Pregabalin is a drug that can cause psychiatric symptoms via pregabalin withdrawal. Prior reports on pregabalin withdrawal have mainly focused on cases with pregabalin dependence or abuse, and little attention has been paid to patients who are prescribed regular doses of pregabalin. Herein, we report three cases of pregabalin withdrawal in patients without psychiatric disorders, taking regular doses of pregabalin, who developed psychiatric symptoms such as insomnia and anxiety after abrupt discontinuation of pregabalin. In addition, we conducted a systematic review of six case reports (previous studies) of pregabalin withdrawal under regular doses of pregabalin. Among the six cases, three patients had no comorbid mental or substance use disorders, the dose of pregabalin ranged from 150 to 600 mg/d, and the duration of pregabalin use ranged from a few weeks to many years. Of these six cases of pregabalin withdrawal, five had psychopathological symptoms, three had vegetative symptoms, and three had neurologic and physical complications. We concluded that since pregabalin withdrawal can occur even with regular doses and short-term use, clinicians must carefully reduce pregabalin doses when reducing or discontinuing treatment, paying close attention to withdrawal symptoms. Our case series sheds light on the scant evidence from previous research on physical dependence in patients who are taking regular doses of pregabalin. Furthermore, our cases were also valuable in demonstrating that pregabalin withdrawal can occur even after a relatively short period of 2 months.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons Inc"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/npr2.12195","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://doi.org/10.1002/npr2.12195"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.1002/npr2.12195","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.© 2021 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2574-173X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Hayahito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeshima, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroyasu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ayabe, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohta, Hidenobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mishima, Kazuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-19"}],"displaytype":"detail","filename":"iA_2022_34.pdf","filesize":[{"value":"293.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_34.pdf","url":"https://air.repo.nii.ac.jp/record/5857/files/iA_2022_34.pdf"},"version_id":"d3a8b172-516b-4c0d-b2de-592105cd83d7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anxiety","subitem_subject_scheme":"Other"},{"subitem_subject":" dependence","subitem_subject_scheme":"Other"},{"subitem_subject":" insomnia","subitem_subject_scheme":"Other"},{"subitem_subject":" pregabalin","subitem_subject_scheme":"Other"},{"subitem_subject":" withdrawal","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-19"},"publish_date":"2023-02-19","publish_status":"0","recid":"5857","relation_version_is_last":true,"title":["Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T10:41:16.519037+00:00"}