{"created":"2023-07-25T10:25:29.363857+00:00","id":5856,"links":{},"metadata":{"_buckets":{"deposit":"861e04ad-37f4-4451-a19a-d5ecbb1187de"},"_deposit":{"created_by":3,"id":"5856","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5856"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005856","sets":["611:939:940"]},"author_link":["16625","16613","16626","16617","16619","16624","16620","16614","16616","16622","16615","16618","16621","16623"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"450","bibliographicPageStart":"444","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Reproductive Medicine and Biology"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Purpose This study investigated the consistency between results of preimplantation genetic testing for aneuploidy performed on trophectoderm (TE) cells and remaining blastocyst cells. Methods TE biopsy was performed on 29 surplus cryopreserved human blastocysts. Biopsy samples and remaining blastocysts were processed using the VeriSeq PGS kit, and chromosomal statuses were compared by next-generation sequencing. Results Discordance was observed in the chromosomal status of 11 out of 29 blastocysts between the biopsied TE and remaining blastocysts. Concordance was observed in 11 of 12 blastocysts classified as euploid by TE biopsy and in 7 of 17 blastocysts classified as aneuploid. There was 100% concordance (7/7) in cases diagnosed as aneuploid with no mosaicism by TE biopsy. However, discordance was observed in all 10 cases showing mosaicism or partial chromosomal abnormality. Conclusion Chromosomal status analysis based on TE biopsy does not accurately reflect the chromosomal status of the whole blastocyst. The chromosomal status is usually the same between the TE and remaining blastocyst cells in cases diagnosed as euploid or aneuploid with no mosaicism. However, mosaic blastocysts and those with other types of structural rearrangements have a higher risk of inconsistency, warranting caution during embryo selection.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons Inc"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/rmb2.12400","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://doi.org/10.1002/rmb2.12400"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.1002/rmb2.12400","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.© 2021 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1445-5781","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Harunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Kazumasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Mayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirakawa, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Hisataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shitara, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwasawa, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Togashi, Kazue"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makino, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirasawa, Hiromitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Wataru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kumazawa, Yukiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terada, Yukihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-19"}],"displaytype":"detail","filename":"iA_2022_33.pdf","filesize":[{"value":"256.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_33.pdf","url":"https://air.repo.nii.ac.jp/record/5856/files/iA_2022_33.pdf"},"version_id":"f84cf228-51a0-47cc-ae27-c181f92b4c2b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"mosaicism","subitem_subject_scheme":"Other"},{"subitem_subject":" next-generation sequencing","subitem_subject_scheme":"Other"},{"subitem_subject":" preimplantation genetic testing","subitem_subject_scheme":"Other"},{"subitem_subject":" trophectoderm","subitem_subject_scheme":"Other"},{"subitem_subject":" whole embryo","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-19"},"publish_date":"2023-02-19","publish_status":"0","recid":"5856","relation_version_is_last":true,"title":["Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T10:41:18.389229+00:00"}