| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-01-30 |
| タイトル |
|
|
タイトル |
Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Carotid plaque |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Delivery |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Gravidity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lacunar |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Menarche |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Menopause |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Plaque |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Reproductive events |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
White matter hyperintensity |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Sato, Wakana
Nomura, Kyoko
Satoh, Michihiro
Hara, Azusa
Tsubota-Utsugi, Megumi
Murakami, Takahisa
Asayama, Kei
Tatsumi, Yukako
Kobayashi, Yuki
Hirose, Takuo
Inoue, Ryusuke
Totsune, Tomoko
Kikuya, Masahiro
Hozawa, Atsushi
Metoki, Hirohito
Imai, Yutaka
Watanabe, Hiroyuki
Ohkubo, Takayoshi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aims: Few studies have investigated the subclinical atherosclerotic changes in the brain and carotid artery, and in East Asian populations. We sought to investigate whether gravidity, delivery, the age at menarche and menopause and estrogen exposure period are associated with subclinical atherosclerosis of the brain and carotid arteriopathy.
Methods: This cross-sectional study formed part of a cohort study of Ohasama residents initiated in 1986. Brain atherosclerosis and carotid arteriopathy were diagnosed as white matter hyperintensity (WMH) and lacunae evident on brain magnetic resonance imaging (MRI) and carotid intimal media thickness (IMT) or plaque revealed by ultrasound, respectively. The effect of the reproductive events on brain atherosclerosis and carotid arteriopathy was investigated using logistic regression and general linear regression models after adjusting for covariates.
Results: Among 966 women aged ≥ 55 years in 1998, we identified 622 and 711 women (mean age: 69.2 and 69.7 years, respectively) who underwent either MRI or carotid ultrasound between 1992–2008 or 1993–2018, respectively. The highest quartile of gravidity (≥ 5 vs. 3) and delivery (≥ 4 vs. 2), and the highest and second highest (3 vs. 2) quartiles of delivery were associated with an increased risk of WMH and carotid artery plaque, respectively. Neither of age at menarche, menopause, and estrogen exposure period estimated by subtracting age at menarche from age at menopause was associated with atherosclerotic changes of brain and carotid arteries.
Conclusions: Higher gravidity and delivery are associated with subclinical atherosclerosis of the brain and carotid plaque. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : Journal of Atherosclerosis and Thrombosis
巻 30,
号 8,
p. 956-978,
発行日 2022
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1340-3478 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1880-3873 |
| 出版者 |
|
|
出版者 |
一般社団法人 日本動脈硬化学会 |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.5551/jat.63592 |
| 権利情報 |
|
|
権利情報 |
©2022 Japan Atherosclerosis SocietyThis article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. |
iA_2022_19.pdf (821.2 kB)
