| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-11-30 |
| タイトル |
|
|
タイトル |
A STUDY OF SERUM ACID SPHINGOMYELINASE ACTIVITY AND CLINICAL SEVERITY IN INFANTS WITH RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
biomarker |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
bronchiolitis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
infant |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
secretory acid sphingomyelinase |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
respiratory syncytial virus |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.20569/00006138 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Yamamoto, Shoko
Noguchi, Atsuko
Hatazawa, Chiaki
Hatazawa, Takako
Kondo, Daiki
Kubota, Hiroki
Tsuchida, Satoko
Takahashi, Tsutomu
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Respiratory syncytial virus (RSV) bronchiolitis is the leading cause of hospitalization in infants without any effective treatment strategies. Identification of biomarkers associated with disease severity may be significant in improving management. However, several studies have failed to identify specific biomarkers for bronchiolitis. Serum secretory acid sphingomyelinase (S-ASM) activity has been considered a biomarker of cytokine release, inflammation, and oxidative stress in various diseases. This study aimed to evaluate whether serum S-ASM activity increases and correlates with disease severity in infants with RSV bronchiolitis. Serum S-ASM activity was measured in 31 infants with RSV bronchiolitis, 9 infants with RSV-negative febrile infection, and 8 healthy infants. Laboratory data and clinical observational findings were analyzed for correlation with serum S-ASM activity. Serum S-ASM activity was significantly higher in the 31 infants with RSV bronchiolitis (9.5±5.4 nmol/mL/h) than individuals in the control groups (RSV-negative febrile infection patients : 4.3±1.9 mol/mL/h, p<0.005 ; healthy infants : 4.0±1.4 nmol/mL/h, p<0.005). Serum S-ASM activity was negatively correlated with interferon-γ levels (rho=−0.448, p=0.012) but not with any other outcomes. Serum S-ASM activity was significantly higher in infants with RSV bronchiolitis than in individuals in the control groups ; however, its clinical significance requires further investigation. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
en : Akita journal of medicine
巻 49,
号 2,
p. 75-82,
発行日 2022-11-30
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0386-6106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai49_2(75).pdf (584.7 kB)
