{"created":"2023-07-25T10:25:26.453765+00:00","id":5782,"links":{},"metadata":{"_buckets":{"deposit":"8a907a4c-4abf-4e9d-a86e-a9555a10e11f"},"_deposit":{"created_by":3,"id":"5782","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5782"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005782","sets":["611:939:940"]},"author_link":["16214","16215","16218","16220","16221","16216","16219","16212","16213","16217","16222"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1542","bibliographicPageStart":"1535","bibliographicVolumeNumber":"171","bibliographic_titles":[{"bibliographic_title":"Surgery"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Background\nThe mechanism underlying cancer cell metastasis from the tumor to regional lymph nodes is not yet fully understood. We hypothesized that peritumoral neutrophil accumulation promotes regional lymph node metastasis in thoracic esophageal squamous cell cancer.\n\nMethods\nBetween 2010 and 2019, 126 thoracic esophageal squamous cell cancer patients received curative (R0) esophagectomy without preoperative treatment in our hospital. Using paraffin-embedded resected tumors, we performed immunohistochemical analysis of CD16b-positive neutrophil accumulation in the peritumoral area, which was defined as a 1-mm region centered on the border separating the malignant cell nests from the host tissue. The relationship between the density of peritumoral CD16b staining and pathological lymph node metastasis or 5-year overall survival was evaluated.\n\nResults\nAlthough the clinicopathological characteristics of CD16b-high and CD16b-low patients did not differ, greater pathological lymph node metastasis (P < .001) and lymphatic invasion by the tumor (P = .024) and a poorer 5-year survival (P = .010) were seen in CD16b-high patients. Moreover, CD16b-positive neutrophil density was generally higher in the peritumoral area than within the tumor itself. Univariate and multivariate analyses showed that CD16b-positive neutrophil accumulation was an independent factor for lymph node metastasis with an odds ratio >25 (P < .001). On the other hand, blood neutrophil counts did not correlate with lymph node metastasis.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.surg.2021.11.022","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1016/j.surg.2021.11.022"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.surg.2021.11.022","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00396060","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Hiromu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motoyama, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"An, Jianbo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagakai, Yushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Tomokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyota, Souichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakita, Akiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imai, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuba, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minamiya, Yoshihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-27"}],"displaytype":"detail","filename":"iA_2022_8.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_8.pdf","url":"https://air.repo.nii.ac.jp/record/5782/files/iA_2022_8.pdf"},"version_id":"9dbd1853-7138-42e4-96ad-b80206748c06"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-27"},"publish_date":"2022-10-27","publish_status":"0","recid":"5782","relation_version_is_last":true,"title":["Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T10:42:57.959598+00:00"}