{"created":"2023-07-25T10:25:26.282281+00:00","id":5778,"links":{},"metadata":{"_buckets":{"deposit":"b36deab2-c01f-4d09-87cb-eb965b4b6924"},"_deposit":{"created_by":3,"id":"5778","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5778"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005778","sets":["611:939:940"]},"author_link":["16198","16200","16194","16196","16199","16197","16195"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Journal of Neurosurgery: Case Lessons"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"BACKGROUND Recent studies report that cerebellar glioblastoma (GBM) is categorized into the RTK1 methylation class. GBM pediatric RTK (pedRTK) subtypes are distinct from those of adult GBM. We present a unique adult case of cerebellar GBM classified into the pedRTK subtype.\nOBSERVATIONS Magnetic resonance imaging revealed a homogeneous enhancing lesion in the right cerebellum in a 56-year-old woman presenting with ataxia and dizziness. Arterial spin labeling and angiographic findings and the intraoperative orange-colored tumor appearance were reminiscent of hemangioblastoma. She showed an atypical presentation in terms of high glucose metabolism. The histological diagnosis was high-grade glioma with differentiation similar to central nervous system neuroblastoma. The methylation class was GBM pedRTK1. Consistent with this classification, immunoexpression was positive for SOX10 and negative for ANKRD55. She underwent craniospinal radiotherapy (23.4 Gy) with a boost to the tumor bed (total 55.8 Gy). Twelve courses of temozolomide therapy were administered. There was no recurrence 18 months after surgery.\nLESSONS Radiological and intraoperative findings, such as hemangioblastoma and high glucose metabolism, were notable characteristics in the present case. Both glial and neuronal differentiation and SOX10 immunoexpression were presenting pathological features. Similar cerebellar GBMs might form a previously unestablished subtype. Establishing effective molecular diagnoses is important.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Journal of Neurosurgery Publishing Group"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3171/CASE2260","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.3171/CASE2260"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3171/CASE2260","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2022 The authors, CC BY-NC-ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-3085","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ono, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hinz, Felix"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Shogo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nanjo, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Deimling, Andreas von"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Hiroaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-24"}],"displaytype":"detail","filename":"iA_2022_1.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_1.pdf","url":"https://air.repo.nii.ac.jp/record/5778/files/iA_2022_1.pdf"},"version_id":"b57fcf26-9448-4a54-b23e-52d9cf91560b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"methylation profile","subitem_subject_scheme":"Other"},{"subitem_subject":"glioblastoma","subitem_subject_scheme":"Other"},{"subitem_subject":"neuroblastoma","subitem_subject_scheme":"Other"},{"subitem_subject":"hemangioblastoma","subitem_subject_scheme":"Other"},{"subitem_subject":"SOX10","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adult cerebellar glioblastoma categorized into a pediatric methylation class with a unique radiological and histological appearance: illustrative case","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adult cerebellar glioblastoma categorized into a pediatric methylation class with a unique radiological and histological appearance: illustrative case"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-24"},"publish_date":"2022-10-24","publish_status":"0","recid":"5778","relation_version_is_last":true,"title":["Adult cerebellar glioblastoma categorized into a pediatric methylation class with a unique radiological and histological appearance: illustrative case"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T10:43:02.872068+00:00"}