{"created":"2023-07-25T10:25:17.860290+00:00","id":5545,"links":{},"metadata":{"_buckets":{"deposit":"c28e78ad-7786-4a1d-8a10-33471e6b9825"},"_deposit":{"created_by":15,"id":"5545","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5545"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005545","sets":["611:939:940"]},"author_link":["15102","15647","15651","10196","15646","15648","15649","15650"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"99","bibliographicPageStart":"95","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"NMC Case Report Journal"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"This paper reports on a case of pilocytic astrocytoma (PA), for which a diagnosis by conventional pathological diagnosis was difficult but an accurate diagnosis was possible by a new molecular diagnostic method. A 13-year-old girl whose tumor developed by a headache that gradually worsened, and a well-demarcated T2-hyperintense lesion was found in the left cerebellum by a magnetic resonance imaging while the apparent diffusion coefficient value was also high. While the finding was a typical PA, histological features of PA were not found in the surgical specimen. An initial diagnosis was anaplastic astrocytoma (AA), and the final diagnosis through a central review was diffuse astrocytoma (DA). On the other hand, using MethylationEPIC (850 K) array, an analysis by a DNA methylation-based tumor classifier tool as reported by Capper et al. showed that this case belonged to a methylation class of PA. The copy number profile calculated from the methylation array data showed hints of BRAF/KIAA1549 fusion and no other chromosomal alterations, which also supported the molecular diagnosis. The patient was treated with local radiotherapy concomitant with temozolomide based on the initial pathological diagnosis during the consultation, but maintenance temozolomide therapy was not done according to the final molecular diagnosis. The tumor showed no recurrence for 20 months. In this case, the integrated diagnostic approach based on histological and molecular findings was clinically significant to select proper adjuvant treatment. It is crucial that the usefulness and robustness of this new molecular diagnostic method be validated further.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Neurosurgical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2176/nmccrj.cr.2018-0282","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2176/nmccrj.cr.2018-0282","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2019 by The Japan Neurosurgical Society This work is licensed under a Creative Commons AttributionNonCommercial-NoDerivatives International License."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-4226","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ono, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatakeyama, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ODA, Masaya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sahm, Felix"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nanjo, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"von Deimling, Andreas"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Hiroaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-04"}],"displaytype":"detail","filename":"iA_2021_39.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","license_note":"CC BY-NC-ND 4.0","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2021_39","url":"https://air.repo.nii.ac.jp/record/5545/files/iA_2021_39.pdf"},"version_id":"03677e22-9af7-4254-aa8d-4f1411eda70f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pilocytic astrocytoma","subitem_subject_scheme":"Other"},{"subitem_subject":"copy number profile","subitem_subject_scheme":"Other"},{"subitem_subject":"methylation profile","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor classifier tool","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical Significance of Molecular Diagnosis of Pilocytic Astrocytoma: A Case Report","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical Significance of Molecular Diagnosis of Pilocytic Astrocytoma: A Case Report"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-04"},"publish_date":"2022-01-04","publish_status":"0","recid":"5545","relation_version_is_last":true,"title":["Clinical Significance of Molecular Diagnosis of Pilocytic Astrocytoma: A Case Report"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:45:49.646466+00:00"}