| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-12-22 |
| タイトル |
|
|
タイトル |
LAMOTRIGINE-RELATED DISSEMINATED INTRAVASCULAR COAGULATION IS MEDIATED BY ANTICONVULSANT HYPERSENSITIVITY SYNDROME : A PHARMACOEPIDEMIOLOGICAL STUDY |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
lamotrigine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
coagulopathy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
anticonvulsant hypersensitivity syndrome |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
adverse event |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
pharmacoepidemiology |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.20569/00005856 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Ishikawa, Hayahito
Takeshima, Masahiro
Ishikawa, Hiroyasu
Mishima, Kazuo
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The relationship between disseminated intravascular coagulation (DIC) and lamotrigine (LTG) use is a controversial topic. We hypothesized that DIC after LTG use is mediated by anticonvulsant hypersensitivity syndrome (AHS), based on our clinical experiences. To examine this hypothesis, a pharmacoepidemiological study was designed using the Japanese Adverse Drug Event Report database (JADER). Twenty-two cases of LTG-related DIC were identified by an exhaustive survey of JADER. AHS triad of fever, skin eruption, and internal organ involvement (indicated by liver dysfunction) were also investigated on each case. Fifty-nine percent of LTGrelated DIC cases had the AHS triad. These results suggest that a distinct etiology, namely AHS or a phenomenon related to this syndrome, is the underlying mechanism of LTG-related DIC. LTG may induce DIC via AHS. More attention should be focused on the risk of DIC with LTG use. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
en : Akita journal of medicine
巻 48,
号 2,
p. 31-35,
発行日 2021-11-30
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0386-6106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
akitai48_2(31) (495.6 kB)
