{"created":"2023-07-25T10:25:16.759947+00:00","id":5520,"links":{},"metadata":{"_buckets":{"deposit":"5165227d-a802-4a67-95a1-a0143b726fef"},"_deposit":{"created_by":15,"id":"5520","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5520"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005520","sets":["611:939:940","920:921:922"]},"author_link":["15548","15549","15550","15551","15552","15553","15554","8893"],"control_number":"5520","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1054","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Biology"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"We evaluated the area under the plasma concentration–time curve (AUC) of afatinib required to avoid the onset of grade 2 or higher diarrhea. The C0 and AUC0–24 of afatinib were significant higher in patients with grade 2 diarrhea than in those with grade 0–1 diarrhea. The areas under the receiver operator curves were 0.795 with the highest sensitivity (89%) and specificity (74%) at an AUC0–24 threshold of 823.5 ng h/mL, and 0.754 with the highest sensitivity (89%) and specificity (74%) at a C0 threshold of 28.5 ng/mL. In Kaplan–Meier analysis based on these cut-off AUC0–24 and C0 values, the median time to the incidence of grade 2 diarrhea was 16 days. The predicted AUC0–24 of afatinib from the single point of C6 showed the highest correlation with the measured AUC0–24 (r2 = 0.840); however, a significant correlation between the AUC0–24 and C0 was also observed (r2 = 0.761). C0 could be used as a marker of therapeutic drug monitoring because afatinib C0 was related to AUC0–24. Therefore, afatinib C0 should be monitored on day 8 after beginning therapy, and the daily dose of afatinib should be adjusted as an index with a cut-off value of 28.5 ng/mL.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/biology10101054","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/biology10101054","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2079-7737","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yokota, Hayato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Sho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okuda, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asano, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeda, Masahide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Katsutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Masatomo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"byoA_2021_1.pdf","filesize":[{"value":"771.5 kB"}],"format":"application/pdf","license_note":"CC BY　4.0","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"byoA_2021_1","url":"https://air.repo.nii.ac.jp/record/5520/files/byoA_2021_1.pdf"},"version_id":"dd7b0459-0c74-4b74-8b9b-ba7787321056"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"afatinib","subitem_subject_scheme":"Other"},{"subitem_subject":"diarrhea","subitem_subject_scheme":"Other"},{"subitem_subject":"limited sampling strategy","subitem_subject_scheme":"Other"},{"subitem_subject":"plasma concentration","subitem_subject_scheme":"Other"},{"subitem_subject":"therapeutic drug monitoring","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between Plasma Concentrations of Afatinib and the Onset of Diarrhea in Patients with Non-Small Cell Lung Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between Plasma Concentrations of Afatinib and the Onset of Diarrhea in Patients with Non-Small Cell Lung Cancer","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940","922"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"5520","relation_version_is_last":true,"title":["Relationship between Plasma Concentrations of Afatinib and the Onset of Diarrhea in Patients with Non-Small Cell Lung Cancer"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-04-01T07:47:57.474964+00:00"}