{"created":"2023-07-25T10:25:15.582623+00:00","id":5491,"links":{},"metadata":{"_buckets":{"deposit":"f4fdefd8-eab6-4d40-b7ee-1657e726d81f"},"_deposit":{"created_by":15,"id":"5491","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5491"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005491","sets":["611:939:940"]},"author_link":["15476","15473","15477","15478","15480","15481","15482"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"399","bibliographicPageStart":"389","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Journal of Diabetes Investigation"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Aims/Introduction: Pharmacological levels of glucagon-like peptide-1 (GLP-1) can decelerate gastric emptying (GE) and reduce postprandial glucose levels. Most previous studies have used liquid meals to evaluate GE. We evaluated the effects of GLP-1 receptor agonists (GLP-1 RAs) on GE and postprandial glucose excursion in Japanese type 2 diabetes mellitus patients using a combination of solid and liquid meals. Materials and Methods: In this single-center, prospective, open-label study, nine healthy individuals and 17 patients with type 2 diabetes mellitus consumed a 460-kcal combination of a solid and liquid meal labeled with 13C-acetic acid. GE was measured from t = 0 to 150 min in a continuous 13C breath test. Eight participants with type 2 diabetes mellitus were administered GLP-1 RAs, and we examined the relationship between GE and blood glucose excursion. Results: There were no differences in the average GE coefficient (GEC) and lag time between the healthy and type 2 diabetes mellitus groups. However, the type 2 diabetes mellitus group showed larger GEC variations (P < 0.05). The coefficient of variation of R-R intervals was a significant predictor of GEC in type 2 diabetes mellitus patients (P < 0.01). The short-acting GLP-1 RA reduced theGEC at 1 month (P = 0.012), whereas the long-acting GLP-1 RA did not significantly change the GEC after treatment. A positive relationship was observed between postprandial glucose excursion from T0 min to T60 min and the GEC (r2 = 0.75; P < 0.01). Conclusions: The reduction in GE rate by the administration of GLP-1 RAs can predict the improvement in postprandial glucose excursion in type 2 diabetes mellitus patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"wiley"}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/jdi.13115","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"©2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd J Diabetes Investig Vol. 11 No. 2 March 2020 389 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. "}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2040-1124","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suganuma, Yumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Tatsunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Takehiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morii, Tsukasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada Sassa , Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Yuichiro ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15482","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-12"}],"displaytype":"detail","filename":"iA_2021_38.pdf","filesize":[{"value":"538.0 kB"}],"format":"application/pdf","licensefree":"CC BY-NC-ND 4.0","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2021_38","url":"https://air.repo.nii.ac.jp/record/5491/files/iA_2021_38.pdf"},"version_id":"50f37108-bb7f-4a60-87c3-89430d6593c1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Continuous 13C breath testGastric emptyingGlucagon-like peptide-1 receptor agonists","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Magnitude of slowing gastric emptying by glucagon-like peptide-1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Magnitude of slowing gastric emptying by glucagon-like peptide-1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-12"},"publish_date":"2021-11-12","publish_status":"0","recid":"5491","relation_version_is_last":true,"title":["Magnitude of slowing gastric emptying by glucagon-like peptide-1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-24T22:35:49.008377+00:00"}