{"created":"2023-07-25T10:25:14.350196+00:00","id":5463,"links":{},"metadata":{"_buckets":{"deposit":"2cd5cd23-fb48-462b-b6a9-8f2f0700ab08"},"_deposit":{"created_by":15,"id":"5463","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5463"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005463","sets":["611:939:940"]},"author_link":["14071","15305"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"1377","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells and are a major source of innate TH2 cytokine secretion upon allergen exposure or parasitic-worm infection. Accumulating studies have revealed that transcription factors, including GATA-3, Bcl11b, Gfi1, ROR , and Ets-1, play a role in ILC2 differentiation. Recent reports have further revealed that the characteristics and functions of ILC2 are influenced by the physiological state of the tissues. Specifically, the type of inflammation strongly affects the ILC2 phenotype in tissues. Inhibitory ILC2s, memory-like ILC2s, and ex-ILC2s with ILC1 features acquire their characteristic properties following exposure to their specific inflammatory environment. We have recently reported a new ILC2 population, designated as exhausted-like ILC2s, which emerges after a severe allergic inflammation. Exhausted-like ILC2s are featured with low reactivity and high expression of inhibitory receptors. Therefore, for a more comprehensive understanding of ILC2 function and differentiation, we review the recent knowledge of transcriptional regulation of ILC2 differentiation and discuss the roles of the Runx transcription factor in controlling the emergence of exhausted-like ILC2s. The concept of exhausted-like ILC2s sheds a light on a new aspect of ILC2 biology in allergic diseases.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms20061377","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms20061377","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12038549","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ebihara, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniuchi, Ichiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-11"}],"displaytype":"detail","filename":"iA_2021_10.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","license_note":"CC BY 4.0","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2021_10","url":"https://air.repo.nii.ac.jp/record/5463/files/iA_2021_10.pdf"},"version_id":"43e95bd7-f61e-4761-a96d-a042042a48f5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"group 2 innate lymphoid cells","subitem_subject_scheme":"Other"},{"subitem_subject":"transcription factor","subitem_subject_scheme":"Other"},{"subitem_subject":"exhausted-like ILC2","subitem_subject_scheme":"Other"},{"subitem_subject":"Runx","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Transcription Factors in the Development and Function of Group 2 Innate Lymphoid Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transcription Factors in the Development and Function of Group 2 Innate Lymphoid Cells"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-11"},"publish_date":"2021-11-11","publish_status":"0","recid":"5463","relation_version_is_last":true,"title":["Transcription Factors in the Development and Function of Group 2 Innate Lymphoid Cells"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:49:23.810922+00:00"}