{"created":"2023-07-25T10:25:14.307487+00:00","id":5462,"links":{},"metadata":{"_buckets":{"deposit":"aee6cb26-0c34-46df-a465-a2303d0cfcd6"},"_deposit":{"created_by":15,"id":"5462","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5462"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005462","sets":["611:939:940"]},"author_link":["15304"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1193","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Cells","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The concept of innate lymphoid cells (ILCs) includes both conventional natural killer (NK) cells and helper ILCs, which resemble CD8+ killer T cells and CD4+ helper T cells in acquired immunity, respectively. Conventional NK cells are migratory cytotoxic cells that find tumor cells or cells infected with microbes. Helper ILCs are localized at peripheral tissue and are responsible for innate helper-cytokine production. Helper ILCs are classified into three subpopulations: TH1-like ILC1s, TH2-like ILC2s, and TH17/TH22-like ILC3s. Because of the functional similarities between ILCs and T cells, ILCs can serve as an innate component that augments each corresponding type of acquired immunity. However, the physiological functions of ILCs are more plastic and complicated than expected and are a ected by environmental cues and types of inflammation. Here, we review recent advances in understanding the interaction between ILCs and acquired immunity, including T- and B-cell responses at various conditions. Immune suppressive activities by ILCs in particular are discussed in comparison to their immune stimulatory e ects to gain precise knowledge of ILC biology and the physiological relevance of ILCs in human diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/cells9051193","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2073-4409","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ebihara, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15304","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-11"}],"displaytype":"detail","filename":"iA_2021_9.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensefree":"CC BY 4.0","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2021_9","url":"https://air.repo.nii.ac.jp/record/5462/files/iA_2021_9.pdf"},"version_id":"16db4d97-fdde-423f-86f0-576ba35c3bd6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"innate lymphoid cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NK cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ILC1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ILC2exhausted-like ILC2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ILC3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-10","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-11"},"publish_date":"2021-11-11","publish_status":"0","recid":"5462","relation_version_is_last":true,"title":["Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-25T04:15:04.602855+00:00"}