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Chromobox 2 Expression Predicts Prognosis after Curative Resection of Oesophageal Squamous Cell Carcinoma
http://hdl.handle.net/10295/00005739
http://hdl.handle.net/10295/0000573958440954-5a5b-4cfc-9f9e-46277c33ec55
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
iA_2021_17 (28.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-08-10 | |||||
| タイトル | ||||||
| タイトル | Chromobox 2 Expression Predicts Prognosis after Curative Resection of Oesophageal Squamous Cell Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 主題 | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Biomarker | |||||
| 主題 | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chromobox 2 (CBX2) | |||||
| 主題 | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | oesophageal squamous cell carcinoma | |||||
| 主題 | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | recurrence | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 作成者 |
UEDA, SEI
× UEDA, SEI× KANDA, MITSURO× SATO, YUSUKE× BABA, HAYATO× NAKAMURA, SHUNSUKE× SAWAKI, KOICHI× SHIMIZU, DAI× MOTOYAMA, SATORU× FUJII, TSUTOMU× KODERA, YASUHIRO× NOMOTO, SHUJI |
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| 内容記述 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim: To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC). Materials and Methods: We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohisto - chemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC. Results: PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR analysis of clinical samples revealed a high tumour-specific CBX2 expression compared with normal oesophageal tissues. High CBX2 expression was significantly associated with shorter disease-specific survival, hematogenous recurrence, and overall recurrence. Analysis of tissue microarrays of one cohort revealed that patients with higher CBX2 levels tended to have a shorter disease-specific survival. Conclusion: CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence. | |||||
| 言語 | en | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 書誌情報 |
en : CANCER GENOMICS & PROTEOMICS 巻 17, p. 391-400, 発行日 2020 |
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| 収録物識別子 | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1790-6245 | |||||
| 出版者 | ||||||
| 出版者 | Cancer Genomics & Proteomics | |||||
| 言語 | en | |||||
| 関連情報 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.21873/cgp.20198 | |||||
