| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-08-10 |
| タイトル |
|
|
タイトル |
Chromobox 2 Expression Predicts Prognosis after Curative Resection of Oesophageal Squamous Cell Carcinoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Biomarker |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chromobox 2 (CBX2) |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oesophageal squamous cell carcinoma |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
recurrence |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
UEDA, SEI
KANDA, MITSURO
SATO, YUSUKE
BABA, HAYATO
NAKAMURA, SHUNSUKE
SAWAKI, KOICHI
SHIMIZU, DAI
MOTOYAMA, SATORU
FUJII, TSUTOMU
KODERA, YASUHIRO
NOMOTO, SHUJI
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background/Aim: To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC). Materials and Methods: We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohisto - chemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC. Results: PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR analysis of clinical samples revealed a high tumour-specific CBX2 expression compared with normal oesophageal tissues. High CBX2 expression was significantly associated with shorter disease-specific survival, hematogenous recurrence, and overall recurrence. Analysis of tissue microarrays of one cohort revealed that patients with higher CBX2 levels tended to have a shorter disease-specific survival. Conclusion: CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : CANCER GENOMICS & PROTEOMICS
巻 17,
p. 391-400,
発行日 2020
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1790-6245 |
| 出版者 |
|
|
出版者 |
Cancer Genomics & Proteomics |
|
言語 |
en |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.21873/cgp.20198 |
iA_2021_17 (28.2 MB)
