@article{oai:air.repo.nii.ac.jp:00003234, author = {浅野, 真理子 and 佐藤, 一洋 and 竹田, 正秀 and 奥田, 佑道 and 須藤, 和久 and 長谷川, 幸保 and 坂本, 祥 and 佐野, 正明 and 渡邊, 博之 and Asano, Mariko and Sato, Kazuhiro and Takeda, Masahide and Okuda, Yuji and Sudo, Kazuhisa and Hasegawa, Yukiyasu and Sakamoto, Sho and Sano, Masaaki and Watanabe, Hiroyuki}, issue = {3/4}, journal = {秋田医学, AKITA JOURNAL OF MEDICINE}, month = {Mar}, note = {A 30-year-old man was admitted because of thirst, polyuria, nausea, vomiting and fever. The electrocardiogram showed QT prolongation, and his chest CT revealed an abnormal lung shadow and systemic multiple lymph node enlargement. The histopathology finding of lymph node biopsy demonstrated a caseating epithelioid granuloma without evidence of tuberculosis. He was diagnosed with sarcoidosis based on diagnostic criteria of sarcoidosis. His brain MRI revealed an intrasellar tumor compressing the pituitary gland, which causes a central nervous system (CNS)involvement of sarcoidosis. The blood examination showed the decreased level of pituitary hormone including of ACTH, TSH, LH, FSH, and ADH. His clinical manifestations and intrasellar lesion was improved with administration of oral steroid, but his hypopituitarism still needed hormone replacement therapy. CNS involvement of sarcoidosis is easy to induce irreversible changes in short term. Our present case indicates the significance of early treatment for sarcoidosis with CNS involvement.}, pages = {155--161}, title = {中枢神経病変により多彩な症状をきたしたサルコイドーシスの一例}, volume = {44}, year = {2018} }