| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-07-05 |
| タイトル |
|
|
タイトル |
DELETERIOUS EFFECTS OF THE PACLITAXEL-COATED BALLOON ON CORONARY MICROCIRCULATION |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
coronary microcirculation |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
microvascular resistance |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
paclitaxel coated balloon |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
percutaneous coronary intervention |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
coronary revascularization |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.20569/00003589 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Seki, Katsuhito
Iino, Kenji
SATO, Teruki
Watanabe, Hiroyuki
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background : Therapeutic options for coronary in-stent restenosis include paclitaxel-coated balloon (PCB), as well as drug eluting stents (DES). A previous basic study has shown that 70% of paclitaxel flows out to the distal coronary artery and only 16% of paclitaxel is transferred to the vessel wall during PCB procedure. However, the effect of PCB on coronary microcirculation remains unknown. The aim of this study was to examine whether PCB impairs coronary microcirculation. Methods and Results : Forty patients who underwent elective coronary revascularization for instent restenosis were randomly assigned to the DES group (n = 20) or the PCB group (n = 20). Coronary microcirculation was evaluated before and after angioplasty by measuring the microvascular resistance (MVR). The baseline characteristics were not different between the two groups. No significant changes were detected in MVR after DES (4.1 ± 0.8 vs. 4.3 ± 1.2, P = 0.17). However, the PCB group revealed a significant increase in MVR after revascularization (from 4.0 ± 0.9 to 6.7 ± 3.7, P < 0.001). Slow flow phenomena emerged in 2 patients who underwent PCB but none with DES. Moreover, relative changes of MVR after angioplasty correlated with the paclitaxel coated area (r= 0.69, P<0.001). Conclusions : These results suggest that PCB impairs the microcirculation. This deleterious effect might be caused in part by distal embolism with coated drug. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
en : Akita journal of medicine
巻 44,
号 3/4,
p. 117-124,
発行日 2018-03
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0386-6106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai44_3_4(117) (750.0 kB)
