| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-08-01 |
| タイトル |
|
|
タイトル |
EFFECT OF DORZOLAMIDE ON RABBIT OCULAR BLOOD FLOW AND ISOLATED CILIARY ARTERY |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dorzolamide |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
phenylephrine |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ocular blood flow |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
myograph |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
WATANABE, Shun
ISHIKAWA, Makoto
YOSHITOMI, Takeshi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background Dorzolamide, the carbonic anhydrase inhibitor, has been reported to have effects on ocular blood flow other than decreasing intraocular pressure (IOP). We investigated the effects of dorzolamide on the phenylephrine induced impairment of rabbit optic nerve head (ONH) blood flow and on phenylephrine induced contraction in isolated rabbit ciliary artery in vitro. Method In male Dutch rabbits, dorzolamide was topically administered after phenylephrine hydrochloride instillation. ONH blood flow was measured by the laser speckle method, which expresses blood velocity as a quantitative index, the mean blur rate (MBR). Also, we investigated the effects of dorzolamide on phenylephrine-induced contractions in rabbit ciliary artery in vitro using isometric tension recording method. Results MBR showed a maximum decrease by 10% compared to that in the baseline value at 120 min after phenylephrine instillation. The phenylephrine-induced decrease was significantly inhibited by dorzolamide at 120 min (P=0.0124). The IOP in the dorzolamide-treated eyes was significantly reduced after phenylephrine instillation. Dorzolamide (30 μM) did not have effect on isolated rabbit ciliary artery which was pre-contracted with 10 μM phenylephrine. Conclusion Topical dorzolamide inhibited phenylephrine induced decrease of ONH circulation in Dutch rabbits. However, dorzolamide did not have effect on isolated rabbit ciliary artery pre-contracted with phenylephrine. It is suggested that the dorzolamide improve the ONH blood flow not by direct action to the vessels. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 42,
号 3/4,
p. 129-135,
発行日 2016-03-31
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai42-3_4(129).pdf (653.7 kB)
