{"created":"2023-07-25T10:23:08.654018+00:00","id":2757,"links":{},"metadata":{"_buckets":{"deposit":"a438fc25-9fe1-44c0-83be-4e3818698853"},"_deposit":{"created_by":3,"id":"2757","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2757"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002757","sets":["611:968:969:1073"]},"author_link":["10152","10151"],"item_10006_alternative_title_32":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"糖尿病自然発症モデルマウス(Akita mice)の骨密度，骨強度の評価"}]},"item_10006_biblio_info_34":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_10006_date_granted_41":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-22"}]},"item_10006_degree_grantor_40":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"秋田大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_39":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_10006_description_27":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Objectives: Diabetes mellitus (DM) causes secondary osteoporosis, which reduces bone mineral density (BMD) and bone strength. Akita mice\n(AM) are DM model mice used to evaluate glucose metabolism. However, bone metabolism in AM remains unclear. The purpose of this study\nwas to evaluate BMD, bone strength, and serum sclerostin levels in AM.\nMethods: Female AM and control mice (C57/BL/6NCrSlc; CM) were divided into four groups: (1) a CM group sacrificed at 14 (CM-14w; n ¼ 8)\nor (2) 18 weeks of age (CM-18w; n ¼ 6); and (3) an AM group sacrificed at 14 (AM-14w; n ¼ 9) or (4) 18 weeks of age (AM-18w; n ¼ 6).\nBlood glucose level, serum sclerostin level, total tibial BMD, and femoral shaft bone strength were evaluated at each time point.\nResults: Blood glucose levels were significantly higher in AM than in CM (p < 0.001). Serum sclerostin levels were significantly lower in AM-\n18w than in CM-18w (p < 0.001). BMD was significantly lower in AM-14w than in CM-14w (p ¼ 0.004). Stiffness of the femoral shaft was\nsignificantly lower in AM-18w than in CM-14w (p ¼ 0.04). Body weight (r ¼ 0.608, p < 0.01) and maximum load (r ¼ 0.438, p < 0.05) were\nsignificantly positively correlated with serum sclerostin levels, while blood glucose levels showed a significant negative correlation (r¼ 0.708,\np < 0.01).\nConclusions: AM showed decreased BMD and bone strength with lower levels of serum sclerostin than CM.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_42":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1152号"}]},"item_10006_publisher_28":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田大学"}]},"item_10006_relation_38":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.afos.2015.09.001","subitem_relation_type_select":"DOI"}}]},"item_10006_rights_31":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"Elsevier"}]},"item_10006_text_36":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文(Osteoporosis and Sarcopenia,1(2),p98-p102掲載論文)"}]},"item_10006_version_type_35":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大内, 賢太郎"}],"nameIdentifiers":[{"nameIdentifier":"10151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OHUCHI, Kentaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10152","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukouyoushi1152.pdf","filesize":[{"value":"327.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨及び審査結果要旨","url":"https://air.repo.nii.ac.jp/record/2757/files/ihakukouyoushi1152.pdf"},"version_id":"ac8b9cfc-2425-459a-b61e-9a59851d65fd"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukou1152.pdf","filesize":[{"value":"480.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://air.repo.nii.ac.jp/record/2757/files/ihakukou1152.pdf"},"version_id":"97c1c03d-9aab-44b5-949f-60ee57bfba63"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Evaluation of bone mineral density and bone strength in autochthonous transgenic model mice for diabetes mellitus (Akita mice)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of bone mineral density and bone strength in autochthonous transgenic model mice for diabetes mellitus (Akita mice)"}]},"item_type_id":"10006","owner":"3","path":["1073"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-06-22"},"publish_date":"2016-06-22","publish_status":"0","recid":"2757","relation_version_is_last":true,"title":["Evaluation of bone mineral density and bone strength in autochthonous transgenic model mice for diabetes mellitus (Akita mice)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T11:36:10.551607+00:00"}