WEKO3
アイテム
Evaluation of bone mineral density and bone strength in autochthonous transgenic model mice for diabetes mellitus (Akita mice)
http://hdl.handle.net/10295/3120
http://hdl.handle.net/10295/3120edb05df7-b73b-40dc-8d4e-e3131a90be54
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
内容要旨及び審査結果要旨 (327.1 kB)
|
|
|
|
本文 (480.1 kB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2016-06-22 | |||||||||
| タイトル | ||||||||||
| タイトル | Evaluation of bone mineral density and bone strength in autochthonous transgenic model mice for diabetes mellitus (Akita mice) | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 別タイトル | ||||||||||
| その他のタイトル | 糖尿病自然発症モデルマウス(Akita mice)の骨密度，骨強度の評価 | |||||||||
| 作成者 |
大内, 賢太郎
× 大内, 賢太郎
× OHUCHI, Kentaro
|
|||||||||
| 内容記述（抄録） | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Objectives: Diabetes mellitus (DM) causes secondary osteoporosis, which reduces bone mineral density (BMD) and bone strength. Akita mice (AM) are DM model mice used to evaluate glucose metabolism. However, bone metabolism in AM remains unclear. The purpose of this study was to evaluate BMD, bone strength, and serum sclerostin levels in AM. Methods: Female AM and control mice (C57/BL/6NCrSlc; CM) were divided into four groups: (1) a CM group sacrificed at 14 (CM-14w; n ¼ 8) or (2) 18 weeks of age (CM-18w; n ¼ 6); and (3) an AM group sacrificed at 14 (AM-14w; n ¼ 9) or (4) 18 weeks of age (AM-18w; n ¼ 6). Blood glucose level, serum sclerostin level, total tibial BMD, and femoral shaft bone strength were evaluated at each time point. Results: Blood glucose levels were significantly higher in AM than in CM (p < 0.001). Serum sclerostin levels were significantly lower in AM- 18w than in CM-18w (p < 0.001). BMD was significantly lower in AM-14w than in CM-14w (p ¼ 0.004). Stiffness of the femoral shaft was significantly lower in AM-18w than in CM-14w (p ¼ 0.04). Body weight (r ¼ 0.608, p < 0.01) and maximum load (r ¼ 0.438, p < 0.05) were significantly positively correlated with serum sclerostin levels, while blood glucose levels showed a significant negative correlation (r¼ 0.708, p < 0.01). Conclusions: AM showed decreased BMD and bone strength with lower levels of serum sclerostin than CM. |
|||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | info:doi/10.1016/j.afos.2015.09.001 | |||||||||
| 書誌情報 | 発行日 2016-06-01 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 秋田大学 | |||||||||
| 著作権等 | ||||||||||
| 権利情報 | Elsevier | |||||||||
| 備考 | ||||||||||
| 秋田大学審査学位論文(Osteoporosis and Sarcopenia,1(2),p98-p102掲載論文) | ||||||||||
| 学位名 | ||||||||||
| 学位名 | 博士(医学) | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 11401 | |||||||||
| 学位授与機関名 | 秋田大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2016-03-22 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第1152号 | |||||||||
