{"created":"2023-07-25T10:23:02.834683+00:00","id":2625,"links":{},"metadata":{"_buckets":{"deposit":"b187feae-717c-4af5-bd48-932aff1179ef"},"_deposit":{"created_by":3,"id":"2625","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2625"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002625","sets":["611:968:969:1073"]},"author_link":["9674","9675"],"item_10006_alternative_title_32":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"大量腸管切除にて腸管細胞内レチノール結合タンパク質 II およびアポリポ タンパク質 A-IV の遺伝子発現が上昇しラット腸管におけるビタミン A 環境 を変化させる"}]},"item_10006_biblio_info_34":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_10006_date_granted_41":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-24"}]},"item_10006_degree_grantor_40":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"秋田大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_39":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_10006_description_27":{"attribute_name":"内容記述(抄録)","attribute_value_mlt":[{"subitem_description":"Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among them, vitamin A is\nimportant for many physiological activities. Vitamin A is taken up by absorptive epithelial cells of the small\nintestine and discharged into lymphatics as a component of chylomicrons and delivered to the liver. Here, we\nused a rat model of SB syndrome to assess its effects on the expression of genes associated with the\nabsorption, transport and metabolism of vitamin A. In SB rats, intestinal expression levels of mRNAs for\ncellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol\nApoa4) were higher than in shams. Absorptive epithelial cells stained positively for both CRBP II and\nlecithin:retinol acyltransferase, both needed for effective esterification of vitamin A. In SB rats, the ileal\nretinol content and the jejunal retinyl esters content were lower than in sham rats. These results suggest that\nthe elevated expression levels of Rbp2 and Apoa4 mRNAs in SB rats contribute to the effective esterification\nand transport of vitamin A.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_42":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1142号"}]},"item_10006_publisher_28":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田大学"}]},"item_10006_relation_38":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3892/ijmm.2015.2066","subitem_relation_type_select":"DOI"}}]},"item_10006_text_36":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文(International Journal o\nf Molecular Medicine,35(3),p724-730掲載論文の著者最終稿)"}]},"item_10006_version_type_35":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"蛇口, 琢"}],"nameIdentifiers":[{"nameIdentifier":"9674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HEBIGUCHI, Taku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9675","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukouyoushi1142.pdf","filesize":[{"value":"876.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨及び審査結果要旨","url":"https://air.repo.nii.ac.jp/record/2625/files/ihakukouyoushi1142.pdf"},"version_id":"d33b4c0e-cb25-486f-9ae9-5084fd7b45d8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukou1142.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://air.repo.nii.ac.jp/record/2625/files/ihakukou1142.pdf"},"version_id":"f8c9cb90-9f6c-4317-9c2d-6691c0beddcf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters intestinal vitamin A status in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters intestinal vitamin A status in rats"}]},"item_type_id":"10006","owner":"3","path":["1073"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-04"},"publish_date":"2015-12-04","publish_status":"0","recid":"2625","relation_version_is_last":true,"title":["Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters intestinal vitamin A status in rats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T11:37:39.702221+00:00"}