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Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters intestinal vitamin A status in rats
http://hdl.handle.net/10295/2968
http://hdl.handle.net/10295/2968b8c00d36-0586-435e-afff-427b800497db
| 名前 / ファイル | ライセンス | アクション |
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内容要旨及び審査結果要旨 (876.4 kB)
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本文 (3.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2015-12-04 | |||||||||
| タイトル | ||||||||||
| タイトル | Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters intestinal vitamin A status in rats | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 別タイトル | ||||||||||
| その他のタイトル | 大量腸管切除にて腸管細胞内レチノール結合タンパク質 II およびアポリポ タンパク質 A-IV の遺伝子発現が上昇しラット腸管におけるビタミン A 環境 を変化させる | |||||||||
| 作成者 |
蛇口, 琢
× 蛇口, 琢
× HEBIGUCHI, Taku
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| 内容記述（抄録） | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among them, vitamin A is important for many physiological activities. Vitamin A is taken up by absorptive epithelial cells of the small intestine and discharged into lymphatics as a component of chylomicrons and delivered to the liver. Here, we used a rat model of SB syndrome to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In SB rats, intestinal expression levels of mRNAs for cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than in shams. Absorptive epithelial cells stained positively for both CRBP II and lecithin:retinol acyltransferase, both needed for effective esterification of vitamin A. In SB rats, the ileal retinol content and the jejunal retinyl esters content were lower than in sham rats. These results suggest that the elevated expression levels of Rbp2 and Apoa4 mRNAs in SB rats contribute to the effective esterification and transport of vitamin A. |
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| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | info:doi/10.3892/ijmm.2015.2066 | |||||||||
| 書誌情報 | 発行日 2015-11-01 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 秋田大学 | |||||||||
| 備考 | ||||||||||
| 秋田大学審査学位論文（International Journal o f Molecular Medicine,35(3),p724-730掲載論文の著者最終稿） |
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| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 11401 | |||||||||
| 学位授与機関名 | 秋田大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2015-09-24 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第1142号 | |||||||||
