{"created":"2023-07-25T10:23:00.044820+00:00","id":2562,"links":{},"metadata":{"_buckets":{"deposit":"a97e665c-16f6-4d64-9285-974c8a224f4a"},"_deposit":{"created_by":3,"id":"2562","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2562"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002562","sets":["611:862:863:1061"]},"author_link":["9448","9449","9446","9447"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"135","bibliographicPageStart":"129","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"秋田医学"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"We recently established mice lacking the type III phosphatidylinositol phosphate kinase gene\n(PipkIII) in enterocytes, which represent a unique model of intestinal inflammation associated\nwith extensive fibrosis that closely resembles human Crohn’s disease. These mutant mice\ndevelop spontaneous juvenile colitis with marked inflammatory cytokine expression, but the primary\npathogenic mechanism remains unclear. In the present study, we found that administration\nof broad-specific antibiotics effectively ameliorated the colitis of PipkIII-deficient mice, suggesting\nthe involvement of intestinal bacterial flora in the onset of colitis. Furthermore, we showed\nthat altered intestinal permeability facilitating commensal bacteria entry putatively caused the\nintestinal inflammation and fibrosis observed in these mutant mice.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAMURA, Ryotaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKASUGA, Shunsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HORIE, Yasuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAKI, Takehiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akitai41-3_4(129).pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akitai41-3_4(129).pdf","url":"https://air.repo.nii.ac.jp/record/2562/files/akitai41-3_4(129).pdf"},"version_id":"85d05a55-5b8b-4fc8-b0e4-15cadd223a1c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PipkIII","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphatidylinositol 3","subitem_subject_scheme":"Other"},{"subitem_subject":"5-bisphosphate","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory bowel disease","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Alterations in Intestinal Permeability Cause Colonic Inflammation and Fibrosis in Type III Phosphatidylinositol Phosphate Kinase-Deficient Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Alterations in Intestinal Permeability Cause Colonic Inflammation and Fibrosis in Type III Phosphatidylinositol Phosphate Kinase-Deficient Mice"}]},"item_type_id":"10001","owner":"3","path":["1061"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-19"},"publish_date":"2015-06-19","publish_status":"0","recid":"2562","relation_version_is_last":true,"title":["Alterations in Intestinal Permeability Cause Colonic Inflammation and Fibrosis in Type III Phosphatidylinositol Phosphate Kinase-Deficient Mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:32:21.523446+00:00"}