{"created":"2023-07-25T10:22:58.615820+00:00","id":2529,"links":{},"metadata":{"_buckets":{"deposit":"2230379a-3f7e-4726-9551-849ff3af1388"},"_deposit":{"created_by":3,"id":"2529","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2529"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002529","sets":["611:968:969:1049"]},"author_link":["9378","9377"],"item_10006_alternative_title_32":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"CRP の抗腫瘍効果 -腫瘍関連マクロファージと腫瘍内血管新生に関して-"}]},"item_10006_biblio_info_34":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_10006_date_granted_41":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-22"}]},"item_10006_degree_grantor_40":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"秋田大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_39":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_27":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Tumor-associated macrophages play a key role in cancer metastasis. On the other hand, Creactive protein (CRP), a widely used biomarker of inflammation, has been shown to have inhibitory effects on tumor proliferation and metastasis. Here we used an implanted tumor mouse model to assess the effect of CRP on tumor-associated macrophage numbers and on their phenotype, as well as on intratumoral angiogenesis. NR-S1M murine oral squamous cell carcinoma cells were implanted subcutaneously in the backs of anesthetized C3H/HeN mice. Some of the mice were also subcutaneously administered 1 μg of recombinant mouse CRP in 100 μL of phosphate-buffered saline (PBS) (CRP group, n = 10) near the neck every 2 days for 30 days (15 injections in all). Control mice received PBS without CRP. The mice were then sacrificed and the excised tumors were analyzed. Tumor weight and size did not differ between the two groups, but immunohistochemical analysis showed the F4/80+ macrophage (total macrophages) count to be significantly larger in the CRP group (P = 0.0028), while the relative number of CD206+ anti-inflammatory M2 macrophages was significantly reduced (P = 0.0091). In addition, expression of colony stimulating factor 1 mRNA, which is associated with the M2 macrophage phenotype, was significantly lower in the CRP group. Intratumoral angiogenesis, indicated by the presence of CD31+ vessels within the tumor, was reduced in the CRP group (P = 0.0028). These findings suggest that CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_42":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1116号"}]},"item_10006_relation_38":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1620/tjem.233.249","subitem_relation_type_select":"DOI"}}]},"item_10006_rights_31":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"東北ジャーナル刊行会"}]},"item_10006_text_36":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文（The Tohoku Journal of Experimental Medicine,233(4),p249-p255掲載論文の著者最終稿）"}]},"item_10006_version_type_35":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"栗林, 邦明"}],"nameIdentifiers":[{"nameIdentifier":"9377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KURIBAYASHI, Kuniaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9378","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakuyoushikou1116.pdf","filesize":[{"value":"781.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨及び審査結果要旨","url":"https://air.repo.nii.ac.jp/record/2529/files/ihakuyoushikou1116.pdf"},"version_id":"1492ca26-4b7e-4b00-9230-dc7d7e5e01d3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihskukou1116.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://air.repo.nii.ac.jp/record/2529/files/ihskukou1116.pdf"},"version_id":"d4ab4fb6-b53e-4d5d-8a03-86f1c6e99379"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Angiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"Colony stimulating factor 1","subitem_subject_scheme":"Other"},{"subitem_subject":"C-reactive protein","subitem_subject_scheme":"Other"},{"subitem_subject":"M2 phenotype","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor-associated","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophages","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"C-Reactive  Protein  Reduces the Relative Number of Tumor -Associated M2 Macrophages  and ntratumoral  Angiogenesis in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C-Reactive  Protein  Reduces the Relative Number of Tumor -Associated M2 Macrophages  and ntratumoral  Angiogenesis in Mice"}]},"item_type_id":"10006","owner":"3","path":["1049"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-12"},"publish_date":"2015-06-12","publish_status":"0","recid":"2529","relation_version_is_last":true,"title":["C-Reactive  Protein  Reduces the Relative Number of Tumor -Associated M2 Macrophages  and ntratumoral  Angiogenesis in Mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:32:28.735891+00:00"}