| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2015-06-12 |
| タイトル |
|
|
タイトル |
C-Reactive Protein Reduces the Relative Number of Tumor -Associated M2 Macrophages and ntratumoral Angiogenesis in Mice |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Angiogenesis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Colony stimulating factor 1 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
C-reactive protein |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
M2 phenotype |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Tumor-associated |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
macrophages |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 別タイトル |
|
|
その他のタイトル |
CRP の抗腫瘍効果 -腫瘍関連マクロファージと腫瘍内血管新生に関して- |
| 作成者 |
栗林, 邦明
KURIBAYASHI, Kuniaki
|
| 内容記述（抄録） |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Tumor-associated macrophages play a key role in cancer metastasis. On the other hand, Creactive protein (CRP), a widely used biomarker of inflammation, has been shown to have inhibitory effects on tumor proliferation and metastasis. Here we used an implanted tumor mouse model to assess the effect of CRP on tumor-associated macrophage numbers and on their phenotype, as well as on intratumoral angiogenesis. NR-S1M murine oral squamous cell carcinoma cells were implanted subcutaneously in the backs of anesthetized C3H/HeN mice. Some of the mice were also subcutaneously administered 1 μg of recombinant mouse CRP in 100 μL of phosphate-buffered saline (PBS) (CRP group, n = 10) near the neck every 2 days for 30 days (15 injections in all). Control mice received PBS without CRP. The mice were then sacrificed and the excised tumors were analyzed. Tumor weight and size did not differ between the two groups, but immunohistochemical analysis showed the F4/80+ macrophage (total macrophages) count to be significantly larger in the CRP group (P = 0.0028), while the relative number of CD206+ anti-inflammatory M2 macrophages was significantly reduced (P = 0.0091). In addition, expression of colony stimulating factor 1 mRNA, which is associated with the M2 macrophage phenotype, was significantly lower in the CRP group. Intratumoral angiogenesis, indicated by the presence of CD31+ vessels within the tumor, was reduced in the CRP group (P = 0.0028). These findings suggest that CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
info:doi/10.1620/tjem.233.249 |
| 書誌情報 |
発行日 2015-06-01
|
| 著作権等 |
|
|
権利情報 |
東北ジャーナル刊行会 |
| 備考 |
|
|
|
秋田大学審査学位論文（The Tohoku Journal of Experimental Medicine,233(4),p249-p255掲載論文の著者最終稿） |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
11401 |
|
|
学位授与機関名 |
秋田大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2015-03-22 |
| 学位授与番号 |
|
|
学位授与番号 |
甲第1116号 |
内容要旨及び審査結果要旨 (781.2 kB)
