| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-06-27 |
| タイトル |
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タイトル |
Long-term effects of post-ischemic estrogen on brain injury in a rat transient forebrain ischemia model |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Nagasaki, G.
Horiguchi, T.
Nishikawa, T.
Masaki, Y.
Tobe, Y.
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| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Post-treatment with estrogen reduced ischemic cerebral injury in some investigations, in which brain injury was evaluated only after a short recovery period. The current study was conducted to compare the effects of post-treatment with estrogen on histological and neurological outcomes after short (7-day) and long (28-day) recovery periods in rats subjected to transient forebrain ischemia. Methods: Male Sprague-Dawley rats were randomly assigned to one of five groups: vehicle (7-day recovery period), vehicle (28-day recovery period), estrogen (17β-estradiol 200 μg/kg, 7-day), estrogen (17β-estradiol 200 μg /kg, 28-day), or sham surgical (n=8 in each group). After forebrain ischemia was induced with bilateral carotid artery occlusion and hemorrhagic hypotension (mean arterial pressure = 40 mmHg) for 10 minutes, the brain was reperfused for 7 days or 28 days. Either 17β-estradiol or vehicle was injected intravenously during the initial 2 minutes of reperfusion. To evaluate histological damage, the number of intact neurons per 1 mm in the hippocampal CA1 subfield was counted at 7 days or 28 days after transient forebrain ischemia. Results: At 7 days after ischemia, the number of intact neurons in the hippocampal CA1 subfield was significantly greater in the estrogen group (57±37/mm: mean±SD) than in the vehicle group (15±15/mm; P=0.01). However, there was no difference between groups at 28 days after ischemia (vehicle: 13±11/mm vs. estrogen: 12±12/mm). Conclusion: The current study indicates that post-ischemic administration of estrogen provided short-term but not long-term neuroprotective effects in transient forebrain ischemia in rats. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
秋田大学審査学位論文の著者稿 |
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言語 |
ja |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 書誌情報 |
en : Acta Anaesthesiologica Scandinavica
巻 57,
号 10,
p. 1245-1252,
発行日 2013-11-01
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| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00015172 |
| 収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00506402 |
| 出版者 |
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出版者 |
John Wiley & Sons |
|
言語 |
en |
| 関連情報 |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1111/aas.12172 |
| 権利者情報 |
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|
権利者名 |
John Wiley & Sons Ltd |
ihakuotsu632.pdf (349.4 kB)
