{"created":"2023-07-25T10:22:48.378202+00:00","id":2294,"links":{},"metadata":{"_buckets":{"deposit":"2075c9cc-5fb3-4201-b373-492cfe67f709"},"_deposit":{"created_by":3,"id":"2294","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2294"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002294","sets":["611:968:969:970"]},"author_link":["8621","8622"],"item_10006_alternative_title_32":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウスB16 メラノーマ細胞におけるカキドオシエキスによるメラニン生成の抑制"}]},"item_10006_biblio_info_34":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_10006_date_granted_41":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-22"}]},"item_10006_degree_grantor_40":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"秋田大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_39":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_27":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Glechoma hederacea L. (Labiatae) has been used in folk medicine to treat various ailments for centuries. We investigated the effects of G. hederacea extract on melanogenesis in B16 melanoma cells. It significantly reduced both the cellular melanin content and tyrosinase activity in a concentration-dependent manner. An MTT assay did not reveal any obvious cytotoxicity. Furthermore, we found that G. hederacea extract decreased tyrosinase and microphthalmia-associated transcription factor protein expression, but did not inhibit tyrosinase-related protein-1 and tyrosinase-related protein-2 expression. RT-PCR analysis indicated that the antimelanogenic effect of G. hederacea extract might be due to inhibition of tyrosinase gene transcription. Moreover, this effect is regulated via suppression of microphthalmia-associated transcription factor protein expression. Our data indicate that G. hederacea extract inhibits melanin synthesis in B16 melanoma cells but is not cytotoxic. Hence it might prove a useful therapeutic agent for treating hyperpigmentation and an effective component of whitening cosmetics.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_42":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1083号"}]},"item_10006_relation_38":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1271/bbb.120341","subitem_relation_type_select":"DOI"}}]},"item_10006_text_36":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文（「Bioscience, Biotechnology, and Biochemistry」,76(10),p1877-p1883掲載論文の著者最終稿）"}]},"item_10006_version_type_35":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"喬, 志偉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"QIAO, ZHIWEI","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukou1083.pdf","filesize":[{"value":"608.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://air.repo.nii.ac.jp/record/2294/files/ihakukou1083.pdf"},"version_id":"46a1ab76-b0e6-4f43-b785-02d931e37daf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"melanogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"Glechoma hederacea","subitem_subject_scheme":"Other"},{"subitem_subject":"tyrosinase","subitem_subject_scheme":"Other"},{"subitem_subject":"tyrosinase-related protein","subitem_subject_scheme":"Other"},{"subitem_subject":"microphthalmia-associated transcription factor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells"}]},"item_type_id":"10006","owner":"3","path":["970"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-25"},"publish_date":"2014-06-25","publish_status":"0","recid":"2294","relation_version_is_last":true,"title":["Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:33:04.590049+00:00"}