{"created":"2023-07-25T10:22:48.334546+00:00","id":2293,"links":{},"metadata":{"_buckets":{"deposit":"ef8357dc-9e6d-45a5-bde6-a1aca82df4bd"},"_deposit":{"created_by":3,"id":"2293","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2293"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002293","sets":["611:968:969:970"]},"author_link":["8619","8620"],"item_10006_alternative_title_32":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"サリノマイシン細胞周期の遅い細胞を含むメラノーマ・スフェロイドの三酸化ヒ素に対する効果を鋭敏化する"}]},"item_10006_biblio_info_34":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_10006_date_granted_41":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-22"}]},"item_10006_degree_grantor_40":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"秋田大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_39":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_27":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Recurrence after chemotherapy is a major cause of cancer mortality: subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to re-propagate the tumor. To develop a novel therapeutic approach for melanoma, we applied a non-adhesive culture system which developed spheroids mimicking the properties of melanoma in vivo. Subsequently, spheroids involved cells exhibiting clonogenic and slow-cycling properties in addition to chemotherapeutic resistance to doxorubicin. Interestingly, while treatment of spheroids with either salinomycin or As_2O_3 showed limiting effects, a combinatorial treatment was markedly superior to single treatment with each drug. Thus, melanoma spheroids could be a new platform for studying melanoma biology and are likely to provide a clinically relevant target for the novel chemotherapy.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_42":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1077号"}]},"item_10006_relation_30":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10295/2504"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10295/2504","subitem_relation_type_select":"HDL"}}]},"item_10006_text_36":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文（秋田医学,40(3/4),p143-p150掲載論文の著者最終稿）"}]},"item_10006_version_type_35":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石河, 軌久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishiga, Norihisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukou1077.pdf","filesize":[{"value":"807.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://air.repo.nii.ac.jp/record/2293/files/ihakukou1077.pdf"},"version_id":"7f85fa60-0f9c-4b0b-8ef6-d534827a1714"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide"}]},"item_type_id":"10006","owner":"3","path":["970"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-23"},"publish_date":"2014-06-23","publish_status":"0","recid":"2293","relation_version_is_last":true,"title":["Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:33:06.098500+00:00"}