@phdthesis{oai:air.repo.nii.ac.jp:00002293,
 author = {石河, 軌久 and Ishiga, Norihisa},
 month = {Jun},
 note = {Recurrence after chemotherapy is a major cause of cancer mortality: subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to re-propagate the tumor. To develop a novel therapeutic approach for melanoma, we applied a non-adhesive culture system which developed spheroids mimicking the properties of melanoma in vivo. Subsequently, spheroids involved cells exhibiting clonogenic and slow-cycling properties in addition to chemotherapeutic resistance to doxorubicin. Interestingly, while treatment of spheroids with either salinomycin or As_2O_3 showed limiting effects, a combinatorial treatment was markedly superior to single treatment with each drug. Thus, melanoma spheroids could be a new platform for studying melanoma biology and are likely to provide a clinically relevant target for the novel chemotherapy.},
 school = {秋田大学},
 title = {Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide},
 year = {2014}
}