| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2014-06-23 |
| タイトル |
|
|
タイトル |
No Involvement of Acid Sphingomyelinase in the Secretion of IL-6 from alveolar Macrophages in neonatal rat |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
chronic lung disease of the newborn |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
alveolar macrophage |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
acid sphingomyelinase |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 別タイトル |
|
|
その他のタイトル |
酸性スフィンゴミエリナーゼはラット肺胞マクロファージからのIL-6 分泌に関与しない |
| 作成者 |
伊藤, 智夫
Ito, Tomoo
|
| 内容記述（抄録） |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Chronic lung disease (CLD) of the newborn is a major problem in neonatology. Activation of alveolar macrophages has been implicated in the pathogenesis of CLD. Acid sphingomyelinase (ASM) responds to diverse cellular stressors, including lipopolysaccharide (LPS) stimulation. Recently, functional inhibitors of acid sphingomyelinase (FIASMAs) have been described as a large group of compounds that inhibit ASM. Here, we used maternal intra-peritoneal LPS injection to model CLD in the infant rat lung. Using this model, we studied ASM activity in the infant rat lung and the effects of FIASMAs on release of interleukin-6 (IL-6) from LPS-stimulated alveolar macrophages. Maternal exposure to LPS non-significantly increased ASM activities in the infant rat lung. FIASMAs significantly decreased ASM activity of LPS-stimulated alveolar macrophages. In addition, some FIASMAs suppressed the release of IL-6 from LPS-stimulated alveolar macrophages during the early response phase. However, FIASMAs did not suppress the release of IL-6 from LPS-stimulated alveolar macrophages. From our study, we could not confirm that ASM activation is responsible for LPS-related pathogenesis of CLD and release of IL-6 from LPS-stimulated alveolar macrophages. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
発行日 2014-06-01
|
| 関連リンク |
|
|
|
識別子タイプ |
HDL |
|
|
関連識別子 |
http://hdl.handle.net/10295/2502 |
|
|
関連名称 |
http://hdl.handle.net/10295/2502 |
| 備考 |
|
|
|
秋田大学審査学位論文（秋田医学,40(3/4),p127-p134掲載論文の著者最終稿） |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
11401 |
|
|
学位授与機関名 |
秋田大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2014-03-22 |
| 学位授与番号 |
|
|
学位授与番号 |
甲第1076号 |
本文 (816.7 kB)
