{"created":"2023-07-25T10:22:48.203606+00:00","id":2290,"links":{},"metadata":{"_buckets":{"deposit":"d9c77a15-a5db-4822-86cb-038fb4213b34"},"_deposit":{"created_by":15,"id":"2290","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2290"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002290","sets":["611:862:863:1003"]},"author_link":["8605","8606","8607","8608"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"150","bibliographicPageStart":"143","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"秋田医学","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Recurrence after chemotherapy is a major cause of cancer mortality : subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to re-propagate the tumor. To develop a novel therapeutic approach for melanoma, we applied a non-adhesive culture system which developed spheroids mimicking the properties of melanoma in vivo. Subsequently, spheroids involved cells exhibiting clonogenic and slow-cycling properties in addition to chemotherapeutic resistance to doxorubicin. Interestingly, while treatment of spheroids with either salinomycin or As_2O_3 showed limiting effects, a combinatorial treatment was markedly superior to single treatment with each drug. Thus, melanoma spheroids could be a new platform for studying melanoma biology and are likely to provide a clinically relevant target for the novel chemotherapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会","subitem_publisher_language":"ja"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Norihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Mayuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noguchi, Natsuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manabe, Motomu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8608","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akitai40-3_4(143).pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akitai40-3_4(143).pdf","url":"https://air.repo.nii.ac.jp/record/2290/files/akitai40-3_4(143).pdf"},"version_id":"fda14fc5-be21-4fa2-9dea-1b64a1ef0236"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Melanoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spheroid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"slow-cycling cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Salinomycin Sensitizes Melanoma Spheroids Containing Slow-Cycling Cells to the Effects of Arsenic Trioxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Salinomycin Sensitizes Melanoma Spheroids Containing Slow-Cycling Cells to the Effects of Arsenic Trioxide","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["1003"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-06-16"},"publish_date":"2014-06-16","publish_status":"0","recid":"2290","relation_version_is_last":true,"title":["Salinomycin Sensitizes Melanoma Spheroids Containing Slow-Cycling Cells to the Effects of Arsenic Trioxide"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-25T09:04:19.097157+00:00"}