| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2014-01-06 |
| タイトル |
|
|
タイトル |
脊椎動物の初期発生においてSox13相同分子種の発現は保存されている |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Sox transcription factor family |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Sox13 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
neural development |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 別タイトル |
|
|
その他のタイトル |
Conserved expression of Sox13 orthologs in early vertebrate development |
| 作成者 |
能登, 舞
Noto, Mai
|
| 内容記述（抄録） |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The skin and nervous tissue is derived from the ectoderm1, 2). In Xenopus, ectodermal explants (animal caps) from blastula embryos show high tissue plasticity and can differentiate into a variety of tissues in vitro. Exploiting this property, we performed a functional screening for factors that can neuralize ectodermal explants, and isolated Xenopus Sox13 (XSox13), a member of the Sox (Sry-related high-mobility-group box) transcription factor family. During Xenopus embryogenesis, XSox13 mRNA is expressed in the entire ectoderm at blastula stages and in the organizer region at gastrula stages. Its expression becomes localized to the neural tube during neurulation and then to somites at tailbud stages. Mouse Sox13mRNA shows similar expression patterns to the Xenopus homolog during embryogenesis: Sox13 is expressed in the node, an equivalent to the Xenopus organizer, at the neural fold stage, exclusively in the nervous tissue at early-mid somite stages, and then showed a segmental expression in the somites at the late somite stage. We next generated Sox13-LacZ-knock-in mice, and examined the expression of mouse Sox13in adult tissues by X-gal staining. In contrast to the expression during embryogenesis, Sox13 is scarcely expressed in the central nervous system in adult. Moreover, Sox13-deficient mice showed no apparent abnormalities in neural development. These results suggest that Sox13 expression in early development is conserved in Xenopus and mouse and Sox13 plays a redundant role during mouse neural development. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
発行日 2013-12-01
|
| 備考 |
|
|
|
秋田大学審査学位論文（秋田医学,40(2),p79-p87掲載論文の著者最終稿） |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
11401 |
|
|
学位授与機関名 |
秋田大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2013-09-25 |
| 学位授与番号 |
|
|
学位授与番号 |
甲1065 |
本文 (4.2 MB)
