{"created":"2023-07-25T10:22:42.115174+00:00","id":2149,"links":{},"metadata":{"_buckets":{"deposit":"c69a1780-0faa-4ff3-8d84-e54ad9aabd3c"},"_deposit":{"created_by":3,"id":"2149","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2149"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002149","sets":["611:968:969:970"]},"author_link":["8206","8207"],"item_10006_alternative_title_32":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Monocyte-derived Dendritic Cells Perform Hemophagocytosis to Fine-tune Excessive Immune Responses"}]},"item_10006_biblio_info_34":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-11-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_10006_date_granted_41":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-09-25"}]},"item_10006_degree_grantor_40":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"秋田大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_39":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_27":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Since immune responses simultaneously defend and injure the host, the immune system must be finely regulated to insure the host's survival. Here, we show that when injected with high TLR ligand doses or infected with LCMV clone 13, which has a high viral turnover, inflammatory monocyte-derived dendritic cells (Mo-DCs) are induced to engulf apoptotic erythroid cells. In this process, called hemophagocytosis, extracellular ATP and phosphatidylserine (PS) serve as “find-me” and “eat-me” signals, respectively. Type I IFNs are necessary for both PS exposure on erythroid cells and the expression of PS receptors in the Mo-DCs. Importantly, hemophagocytosis is required for IL-10 production from Mo-DCs. Blocking hemophagocytosis or Mo-DC-derived IL-10 significantly increases CTL activity, tissue damage, and mortality in virus-infected hosts, suggesting that hemophagocytosis moderates immune responses to assure the host’s survival in vivo. This sheds light on the induction mechanisms and physiological relevance of hemophagocytosis in severe inflammatory and infectious diseases.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_42":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1060"}]},"item_10006_relation_30":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencedirect.com/science/article/pii/S107476131300349X"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/article/pii/S107476131300349X","subitem_relation_type_select":"URI"}}]},"item_10006_text_36":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文（Immunity,39(3),p584-p598掲載論文の著者最終原稿）"}]},"item_10006_version_type_35":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大八木, 秀明"}],"nameIdentifiers":[{"nameIdentifier":"8206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyagi, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8207","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihaku1060.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://air.repo.nii.ac.jp/record/2149/files/ihaku1060.pdf"},"version_id":"4a512762-5341-485d-a5dc-e05da5562e11"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する"}]},"item_type_id":"10006","owner":"3","path":["970"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-06"},"publish_date":"2014-01-06","publish_status":"0","recid":"2149","relation_version_is_last":true,"title":["血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:33:19.729561+00:00"}