| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2014-01-06 |
| タイトル |
|
|
タイトル |
血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 別タイトル |
|
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その他のタイトル |
Monocyte-derived Dendritic Cells Perform Hemophagocytosis to Fine-tune Excessive Immune Responses |
| 作成者 |
大八木, 秀明
Ohyagi, Hideaki
|
| 内容記述（抄録） |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Since immune responses simultaneously defend and injure the host, the immune system must be finely regulated to insure the host's survival. Here, we show that when injected with high TLR ligand doses or infected with LCMV clone 13, which has a high viral turnover, inflammatory monocyte-derived dendritic cells (Mo-DCs) are induced to engulf apoptotic erythroid cells. In this process, called hemophagocytosis, extracellular ATP and phosphatidylserine (PS) serve as “find-me” and “eat-me” signals, respectively. Type I IFNs are necessary for both PS exposure on erythroid cells and the expression of PS receptors in the Mo-DCs. Importantly, hemophagocytosis is required for IL-10 production from Mo-DCs. Blocking hemophagocytosis or Mo-DC-derived IL-10 significantly increases CTL activity, tissue damage, and mortality in virus-infected hosts, suggesting that hemophagocytosis moderates immune responses to assure the host’s survival in vivo. This sheds light on the induction mechanisms and physiological relevance of hemophagocytosis in severe inflammatory and infectious diseases. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
発行日 2013-11-01
|
| 関連リンク |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.sciencedirect.com/science/article/pii/S107476131300349X |
|
|
関連名称 |
http://www.sciencedirect.com/science/article/pii/S107476131300349X |
| 備考 |
|
|
|
秋田大学審査学位論文（Immunity,39(3),p584-p598掲載論文の著者最終原稿） |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
11401 |
|
|
学位授与機関名 |
秋田大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2013-09-25 |
| 学位授与番号 |
|
|
学位授与番号 |
甲1060 |
本文 (1.7 MB)
