{"created":"2023-07-25T10:22:36.372010+00:00","id":2017,"links":{},"metadata":{"_buckets":{"deposit":"72160d39-9a25-4f8b-a30c-f861c0bf7fcf"},"_deposit":{"created_by":3,"id":"2017","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2017"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002017","sets":["611:862:863:938"]},"author_link":["7569","7568","7564","7565","7570","7566","7567"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"101","bibliographicPageStart":"95","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"秋田医学"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Reactive oxygen species (ROS) production by neutrophils is essential for host innate immune defense. However, although ROS production is advantageous for killing various infectious organisms, excessive ROS can cause tissue damage. Thus, ROS production by neutrophils must be tightly controlled.　In this study, we investigated a role for SH2 domain-containing inositol- 5-phosphatase 1 (SHIP1), a PtdIns(3,4,5)P3 phosphatase, in ROS production by neutrophils using ship1−/− mice. SHIP1 deletion enhanced ROS production as well as the bacterial killing capability of neutrophils. However, the ship1−/− mice showed decreases survival of the mice infected with Staphylococcus aureus (S. aureus). Our results suggest that SHIP1 controls appropriate host defenses against S. aureus infections in mice.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chida, Shinsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Reietsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kofuji, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takasuga, Shunsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Junko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Takehiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akitai39(95).pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akitai39(95).pdf","url":"https://air.repo.nii.ac.jp/record/2017/files/akitai39(95).pdf"},"version_id":"440e3170-dbc6-485a-a5f4-42bdcf836249"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Reactive oxygen species","subitem_subject_scheme":"Other"},{"subitem_subject":"NADPH oxidase","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil","subitem_subject_scheme":"Other"},{"subitem_subject":"phospholipid","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SHIP1 DELETION ENHANCES ROS PRODUCTION AND DECREASES SURVIVAL OF THE S. AUREUS INFECTED MICE","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SHIP1 DELETION ENHANCES ROS PRODUCTION AND DECREASES SURVIVAL OF THE S. AUREUS INFECTED MICE"}]},"item_type_id":"10001","owner":"3","path":["938"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-29"},"publish_date":"2013-05-29","publish_status":"0","recid":"2017","relation_version_is_last":true,"title":["SHIP1 DELETION ENHANCES ROS PRODUCTION AND DECREASES SURVIVAL OF THE S. AUREUS INFECTED MICE"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:33:28.878147+00:00"}