| Item type |
デフォルトアイテムタイプ（シンプル）(1) |
| 公開日 |
2025-07-04 |
| タイトル |
|
|
タイトル |
CLINICAL SIGNIFICANCE OF URINARY SECRETORY ACID SPHINGOMYELINASE ACTIVITY IN PEDIATRIC PATIENTS WITH RENAL DISEASES |
|
言語 |
en |
| 作成者 |
Misato, Narumi
Hiroaki, Tamura
Atsuko, Noguchi
Akie, Kato
Osamu, Takeda
Masaya, Saito
Tsutomu, Takahashi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
acid sphingomyelinase |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fractional excretion |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IgA nephritis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
renal diseases |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
urinary activity |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Acid sphingomyelinase (ASM) is activated in various human diseases. Secretion of ASM (S-ASM) is accompanied by its activation, which clinically leads to elevated S-ASM activity in blood and urine. Here, serum and urinary levels of S-ASM activity were determined in patients with chronic diseases, which were divided into non-renal and renal groups depending on the etiology of the diseases. In 28 patients with non-renal diseases, serum and urinary S-ASM activities were 7.40 ± 0.28 nmol/ml/h and 0.28 ± 0.35 nmol/mgCr/h, respectively. A significant correlation was found between the two S-ASM activities in this group (r = 0.539, p < 0.05). Conversely, among 12 patients with renal diseases, serum S-ASM activities were not elevated (3.99 ± 1.48 nmol/ml/h); however, urinary activities had increased to 0.35 ± 0.50 nmol/mgCr/h. Fractional S-ASM excretion (FE S-ASM) was calculated for both groups, yielding 0.011 ± 0.01 % in non-renal group and 0.030 ± 0.045 % in renal group. Individually, a patient with IgA nephritis demonstrated significantly elevated urinary S-ASM activities and increased FE S-ASM activity, suggesting aberrant dynamics of S-ASM in the kidney caused by the pathogenesis of IgA nephritis. This study indicates that urinary S-ASM activity could reflect the pathological state of renal diseases. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Akita Medical Society |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子（シンプル） |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ（シンプル） |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.20569/0002001697 |
|
ID登録タイプ |
JaLC |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2759-5226 |
| 書誌情報 |
en : Akita journal of medicine
ja : 秋田医学
巻 51,
号 2-4,
p. 89-96,
発行日 2024-11-30
|
akitai51_2-4(89).pdf (3.0 MB)
