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アイテム
SERUM SECRETORY ACID SPHINGOMYELINASE ACTIVITY AS A POTENTIAL BIOMARKER OF OBESITY AND ITS COMORBIDITIES IN CHILDREN AND ADOLESCENTS: A STUDY OF PEDIATRIC OUT-PATIENTS
https://doi.org/10.20569/0002001696
https://doi.org/10.20569/0002001696965bb9e2-cf88-4661-b31d-b7dc0b3ad2f1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
akitai51_2-4(81).pdf (2.2 MB)
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| Item type | デフォルトアイテムタイプ（シンプル）(1) | |||||||||||||||||||
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| 公開日 | 2025-07-04 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | SERUM SECRETORY ACID SPHINGOMYELINASE ACTIVITY AS A POTENTIAL BIOMARKER OF OBESITY AND ITS COMORBIDITIES IN CHILDREN AND ADOLESCENTS: A STUDY OF PEDIATRIC OUT-PATIENTS | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 作成者 |
Shin, Otaka
× Shin, Otaka
× Ikuko, Takahashi
× Atsuko, Noguchi
× Akie, Kato
× Masataka, Inoue
× Hiroki, Nakanishi
× Tsutomu, Takahashi
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| アクセス権 | ||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | acid sphingomyelinase | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | ceramide | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | metabolic dysfunction-associated steatotic liver disease | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | obesity | |||||||||||||||||||
| 主題 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | sphingomyelin | |||||||||||||||||||
| 内容記述 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Background: Obesity is a major health concern for both children and adults. Although various biomarkers have been proposed to monitor health in managing obesity, further exploration of key biological factors is needed in clinical practice. Objectives: This study aims to evaluate serum secretory acid sphingomyelinase （S-ASM） activity as a biomarker for obesity and its related conditions. Methods: Forty-seven individuals with obesity （percentage of overweight （POW） ≥ 20%） were divided into groups with mild to moderate obesity （POW < 50%） and severe obesity （POW ≥ 50%）. Serum S-ASM activity was measured and compared between these groups. Correlations with liver enzyme ratios and S-ASM's diagnostic performance for obesity-related liver dysfunction were assessed using receiver operating characteristic curve analysis. Results: Serum S-ASM activity was higher in the severe obesity group（ 7.2 ± 3.6 nmol/ml/h） compared to the mild to moderate obesity group（ 4.7 ± 2.2 nmol/ml/h, p=0.03）. Serum S-ASM activity negatively correlated with the aspartate aminotransferase/alanine aminotransferase ratio（ r = -0.389, p < 0.01）. The area under the curve for diagnosing obesity-related liver dysfunction was 0.732（ cut-off 4.70 nmol/ml/h, sensitivity 0.75, specificity 0.78, p=0.006）. Conclusions: Serum S-ASM activity is a potential biomarker for obesity-related comorbidities, particularly liver dysfunction, in children and adolescents. |
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| 言語 | en | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | Akita Medical Society | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子（シンプル） | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ（シンプル） | journal article | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| ID登録 | ||||||||||||||||||||
| ID登録 | 10.20569/0002001696 | |||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 2759-5226 | |||||||||||||||||||
| 書誌情報 |
en : Akita journal of medicine ja : 秋田医学 巻 51, 号 2-4, p. 81-88, 発行日 2024-11-30 |
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