WEKO3
アイテム
THE PREDICTORS OF LEFT VENTRICULAR REVERSE REMODELING AFTER RENAL TRANSPLANTATION
https://doi.org/10.20569/0002001688
https://doi.org/10.20569/0002001688aa772fdd-0a30-42b9-b298-582fb1430545
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
akitai50_3_4(133).pdf (792.2 KB)
|
|
| Item type | デフォルトアイテムタイプ（シンプル）(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-07-03 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | THE PREDICTORS OF LEFT VENTRICULAR REVERSE REMODELING AFTER RENAL TRANSPLANTATION | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 作成者 |
Ken, Miura
× Ken, Miura
× Teruki, Sato
× Takako, Iino
× Wakana, Sato
× Shigeru, Satoh
× Hiroyuki, Watanabe
|
|||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | end-stage renal disease | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | renal transplantation | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | left ventricular remodeling | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | hypertension | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Background and purpose : Renal transplantation (RT) is known to induce the regression of left ventricular (LV) hypertrophy and leads to LV reverse remodeling. However, the underlying mechanisms of the structural improvement have not been evaluated, and not everyone with RT respond well. The aim of this study was to clarify the underlying mechanisms of LV reverse remodeling after RT. In addition, we aimed to identify the contributor associated with LV reverse remodeling. Methods : Sixty-four end-stage renal disease patients with LV hypertrophy (LV mass index ≥115 g/m2 in men and ≥95 g/m2 in women) who underwent RT were enrolled. The echocardiographic data and home blood pressure (BP) measurements were obtained before RT, at 1-, 6-, and 12-month after RT. 123I-MIBG myocardial scintigraphy were performed before and 6-month after RT. RT responders was defined as ≥20% reduction of LV mass index (LVMI) at 12-month after RT. Results : Twenty-seven patients (42%) were classified into responders. At baseline, responders were characterized by higher LVMI compared with non-responders (152±32 vs. 127±24 g/m2, p<0.001) and preoperative heart rate was significantly lower in responders than that in nonresponders (71±15 vs. 78±11 beats/min, p<0.05). No other parameters including baseline characteristics and echocardiographic data had significant power to extract responders. However, systolic and diastolic BPs decreased significantly in responders (p<0.0001, p<0.0001, respectively), but not obvious in non-responders after RT. The post-transplant eGFR at 1-month after RT was significantly lower in non-responders than that in responders (p<0.05), whereas there was no significant difference in eGFR at 12-month after RT. In the multiple linear regression analysis, high BMI and LVMI at baseline, low eGFR at 1-month after RT were independent risk factors to result in non-responder. Conclusion : RT leads to LV reverse remodeling through improvement of pressure overload and renal function. Thus, the eGFR at 1-month after RT and BMI value before RT could be the predictor of LV reverse remodeling. |
|||||||||||||||||
| 言語 | en | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Akita Medical Society | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子（シンプル） | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ（シンプル） | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| ID登録 | ||||||||||||||||||
| ID登録 | 10.20569/0002001688 | |||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 0386-6106 | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AN00009294 | |||||||||||||||||
| 書誌情報 |
en : Akita journal of medicine ja : 秋田医学 巻 50, 号 3/4, p. 133-142, 発行日 2024-03-29 |
|||||||||||||||||
