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TEMPORAL CHANGES IN CEREBRAL BLOOD FLOW AND DEVELOPMENT OF COLLATERAL PATHWAYS IN A RAT MODEL OF ACUTE SUPERIOR SAGITTAL SINUS OCCLUSION INDUCED BY GELATIN SPONGE INSERTION
https://doi.org/10.20569/0002001539
https://doi.org/10.20569/00020015391ff39c93-a93f-4e4a-9af6-c3e5442293f1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
akitai52_1(1).pdf (4.6 MB)
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||||||||
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| 公開日 | 2025-06-09 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | TEMPORAL CHANGES IN CEREBRAL BLOOD FLOW AND DEVELOPMENT OF COLLATERAL PATHWAYS IN A RAT MODEL OF ACUTE SUPERIOR SAGITTAL SINUS OCCLUSION INDUCED BY GELATIN SPONGE INSERTION | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Hamasaki, Ryo
× Hamasaki, Ryo
× Abe, Takatsugu
× Ono, Takahiro
× Bando, Yoshio
× Shimizu, Hiroaki
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| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | cerebral blood flow | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | rat model | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | superior sagittal sinus | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | venous sinus occlusion | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | OBJECTIVE: This study aimed to investigate the temporal changes in cerebral blood flow（ CBF） upon superior sagittal sinus（ SSS） occlusion in a novel rat model. METHODS: A gelatin sponge was inserted into the SSS to obtain immediate and complete SSS occlusion. A laser speckle flowmetry （LSF） was employed to monitor the CBF of the parasagittal cortex for 100 minutes post-procedure, and on days 1-3 after occlusion. Regions of interests for CBF were placed in an area between the two occluded bridging veins（ 2VOA）, or an area adjacent to only one occluded bridging vein（ 1VOA）. Histopathological evaluation was performed 3 days following SSS occlusion. RESULT: The CBF in the parasagittal cortices following the SSS occlusion acutely decreased to approximately 70% and 80% in the 2VOA and 1VOA compared to the pre-occlusion levels, respectively. Development of collateral anastomosis between the bridging veins was observed by 60 minutes following occlusion, and CBF recovered on day 1. Pathologically, edematous changes were more evident in the 2VOA than the 1VOA. Conclusions: CBF reduction in the parasagittal cortices depended on the severity of adjacent venous occlusion. Development of collateral venous anastomosis seemed to contribute for the CBF recovery. |
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| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | AKITA MEDICAL SOCIETY | |||||||||||||||
| 言語 | en | |||||||||||||||
| 日付 | ||||||||||||||||
| 日付 | 2024-12-27 | |||||||||||||||
| 日付タイプ | Accepted | |||||||||||||||
| 日付 | ||||||||||||||||
| 日付 | 2025-03-31 | |||||||||||||||
| 日付タイプ | Issued | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.20569/0002001539 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 書誌情報 |
en : AKITA JOURNAL OF MEDICINE 巻 52, 号 1, p. 1-7, 発行日 2025-03-31 |
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