| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-01-10 |
| タイトル |
|
|
タイトル |
DIAMETER OF HUMAN DAY 6 BLASTOCYSTS REFLECTS THE GENETIC HOMOGENEITY OF TROPHECTODERM COMPONENTS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aneuploidy |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
blastocyst |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mosaicism |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nextgeneration sequencing |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
reproduction |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.20569/0002000071 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Hasegawa, Hisataka
Takahashi, Kazumasa
Kobayashi, Tatsuya
Iwasawa,Takuya
Fujishima, Akiko
Togashi, Kazue
Kenichi Makino
Shirasawa, Hiromitsu
Miura, Hiroshi
Sato, Wataru
Kumazawa, Yukiyo
Kobayashi, Junichi
Terada, Yukihiro
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background : Aneuploid embryos have also been reported to expand, albeit at a slower rate than euploid embryos. Accordingly, we hypothesized that embryonic expansion is related to chromosomal homogeneity. The aim of this study was to investigate why blastocyst expansion is an independent predictor of pregnancy during blastocyst transfer cycles in assisted reproductive technology. This retrospective preliminary study was performed using 103 surplus embryos from 53 couples who opted for assisted reproductive technology at a single center in 2019.
Results : The inner diameter of euploid blastocysts (187.6±10.9 μm, n=23) and aneuploid blastocysts (184.0±14.2 μm, n=31) did not differ significantly. However, the inner diameter of mosaic blastocysts (178.6±11.8 μm, n=49) was significantly smaller (P<0.01) than that of euploid blastocysts. The inner diameter of blastocysts and patient characteristics or morphological grading of blastocysts did not significantly differ. In the multivariate analysis, the inner diameter of blastocysts was an independent variable predicting mosaic blastocysts (adjusted odds ratio : 0.95 ; 95% confidence interval : 0.92-0.99 ; P<0.01).
Conclusion : The day 6 blastocyst-expansion ability reflects chromosomal mosaicism of the trophectoderm independent of patient characteristics and the morphological grading of blastocysts. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
en : Akita journal of medicine
巻 50,
号 2,
p. 63-71,
発行日 2023-11-30
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| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0386-6106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai50_2(63).pdf (692 KB)
